Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | INSR | P06213 | 2/20 | 0.40 |
| ▸ | IGF1R | P08069 | 2/20 | 0.40 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.40 |
| ▸ | CDK7 | P50613 | 1/20 | 0.39 |
| ▸ | CDK9 | P50750 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MAP4K1 | Q92918 | 8/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PTK2 | Q05397 | 5/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30379728 | 1.00 | INSR (0.40) | INSRIGF1RALKCDK7CDK9 | |
| SCHEMBL30379918 | 0.81 | CDK7 (0.39) | INSRIGF1RALKCDK7CDK9 | |
| SCHEMBL28546927 | 0.81 | CDK7 (0.39) | INSRIGF1RALKCDK7CDK9 | |
| SCHEMBL23487589 | 0.80 | PTK2 (0.50) | INSRIGF1RMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL21600832 | 0.80 | CDK7 (0.38) | INSRIGF1RALKCDK7CDK9 | |
| SCHEMBL21600835 | 0.79 | KDM4E (0.40) | KDM4EMAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL23461740 | 0.78 | SLC2A1 (0.57) | INSRIGF1RALKCDK7CDK9 | |
| SCHEMBL5257876 | 0.77 | KDM4E (0.54) | KDM4EALDH1A1LMNA | |
| SCHEMBL23487264 | 0.77 | PKMYT1 (0.46) | KDM4EMAPTALDH1A1SMN1; SMN2PTK2 | |
| SCHEMBL28537329 | 0.76 | PTK2 (0.37) | CDK7CDK9PTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112313207-B | Cyano-substituted pyridine and cyano-substituted pyrimidine compounds, and preparation methods and applications thereof | 北京赛特明强医药科技有限公司 | 2023-02-14 | — | — | CN | disclosed |
| CN-112313207-A | Cyano-substituted pyridine and cyano-substituted pyrimidine compounds, and preparation methods and applications thereof | 北京赛特明强医药科技有限公司 | 2021-02-02 | — | — | CN | disclosed |
| WO-2019242689-A1 | CYANO-SUBSTITUTED PYRIDINE AND CYANO-SUBSTITUTED PYRIMIDINE COMPOUND, AND PREPARATION METHOD AND APPLICATION THEREOF | 北京赛特明强医药科技有限公司 | 2019-12-26 | — | — | WO | disclosed |
| WO-2019242689-A1 | CYANO-SUBSTITUTED PYRIDINE AND CYANO-SUBSTITUTED PYRIMIDINE COMPOUND, AND PREPARATION METHOD AND APPLICATION THEREOF | 北京赛特明强医药科技有限公司 | 2019-12-26 | — | — | WO | disclosed |