Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.36 |
| ▸ | KDR | P35968 | 2/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | CASP7 | P55210 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5257876 | 0.79 | KDM4E (0.54) | KDM4EALDH1A1SYKAURKAKDR | |
| SCHEMBL21596403 | 0.79 | INSR (0.40) | KDM4EALDH1A1MAPTSMN1; SMN2LMNA | |
| SCHEMBL30379728 | 0.79 | INSR (0.40) | KDM4EALDH1A1MAPTSMN1; SMN2LMNA | |
| SCHEMBL23461740 | 0.78 | SLC2A1 (0.57) | ALDH1A1MAPTSMN1; SMN2SYKAURKA | |
| SCHEMBL23487589 | 0.77 | PTK2 (0.50) | ALDH1A1MAPTSMN1; SMN2SLC2A1PKMYT1 | |
| SCHEMBL23487626 | 0.76 | SLC2A1 (0.42) | KDM4EALDH1A1MAPTSMN1; SMN2SYK | |
| SCHEMBL23460412 | 0.75 | AKT1 (0.48) | KDM4E | |
| SCHEMBL23487619 | 0.75 | KDM4E (0.39) | KDM4EALDH1A1MAPTSMN1; SMN2SYK | |
| SCHEMBL23487625 | 0.74 | KDM4E (0.38) | KDM4EALDH1A1MAPTSMN1; SMN2SYK | |
| SCHEMBL25339562 | 0.74 | KDM4E (0.36) | KDM4EALDH1A1MAPTSMN1; SMN2SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019242689-A1 | CYANO-SUBSTITUTED PYRIDINE AND CYANO-SUBSTITUTED PYRIMIDINE COMPOUND, AND PREPARATION METHOD AND APPLICATION THEREOF | 北京赛特明强医药科技有限公司 | 2019-12-26 | — | — | WO | disclosed |