Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | REV1 | Q9UBZ9 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | CNR2 | P34972 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | NPY1R | P25929 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28607689 | 1.00 | KDM4E (0.41) | KDM4EMAPTHSD17B10FLT3ALDH1A1 | |
| SCHEMBL21597804 | 0.83 | MAPT (0.37) | KDM4EMAPTHSD17B10FLT3ALDH1A1 | |
| SCHEMBL28610714 | 0.82 | ALDH1A1 (0.39) | KDM4EMAPTHSD17B10FLT3ALDH1A1 | |
| SCHEMBL21597730 | 0.78 | FLT3 (0.60) | KDM4EMAPTHSD17B10FLT3ALDH1A1 | |
| SCHEMBL21597538 | 0.78 | KMT2A (0.54) | KDM4EMAPTHSD17B10ALDH1A1GAA | |
| SCHEMBL21597372 | 0.77 | CNR2 (0.46) | KDM4EMAPTHSD17B10FLT3ALDH1A1 | |
| SCHEMBL21597477 | 0.77 | REV1 (0.44) | KDM4EMAPTHSD17B10FLT3ALDH1A1 | |
| SCHEMBL21603849 | 0.77 | REV1 (0.44) | KDM4EMAPTHSD17B10FLT3ALDH1A1 | |
| SCHEMBL21597559 | 0.77 | EPHX2 (0.45) | KDM4EMAPTHSD17B10ALDH1A1GAA | |
| SCHEMBL21597875 | 0.75 | KDM4E (0.60) | KDM4EMAPTHSD17B10FLT3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3810606-A1 | THIOPHENE DERIVATIVES FOR THE TREATMENT OF DISORDERS CAUSED BY IGE | UCB Biopharma SRL (BE) | 2021-04-28 | — | — | EP | disclosed |
| WO-2019243550-A1 | THIOPHENE DERIVATIVES FOR THE TREATMENT OF DISORDERS CAUSED BY IGE | UCB Biopharma SRL (BE) | 2019-12-26 | — | — | WO | disclosed |