Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.54 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.50 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.49 |
| ▸ | DRD3 | P35462 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.49 |
| ▸ | HTR1A | P08908 | 2/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.49 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.49 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.49 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.49 |
| ▸ | DRD1 | P21728 | 2/20 | 0.49 |
| ▸ | HTR2A | P28223 | 2/20 | 0.49 |
| ▸ | HTR2C | P28335 | 2/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.49 |
| ▸ | HRH1 | P35367 | 2/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.49 |
| ▸ | HTR2B | P41595 | 2/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.49 |
| ▸ | DRD4 | P21917 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2159819 | 1.00 | DRD2 (0.54) | DRD2HRH4CHRM1DRD3LMNA | |
| SCHEMBL2159782 | 1.00 | DRD2 (0.54) | DRD2HRH4CHRM1DRD3LMNA | |
| SCHEMBL12395973 | 1.00 | DRD2 (0.54) | DRD2HRH4CHRM1DRD3LMNA | |
| SCHEMBL2159818 | 1.00 | DRD2 (0.54) | DRD2HRH4CHRM1DRD3LMNA | |
| SCHEMBL12395971 | 0.90 | HRH4 (0.45) | DRD2HRH4CHRM1DRD3LMNA | |
| SCHEMBL2158842 | 0.90 | HRH4 (0.45) | DRD2HRH4CHRM1DRD3LMNA | |
| SCHEMBL2158837 | 0.90 | HRH4 (0.45) | DRD2HRH4CHRM1DRD3LMNA | |
| SCHEMBL2159635 | 0.90 | HRH4 (0.45) | DRD2HRH4CHRM1DRD3LMNA | |
| SCHEMBL2159639 | 0.90 | HRH4 (0.45) | DRD2HRH4CHRM1DRD3LMNA | |
| SCHEMBL3468597 | 0.89 | DRD2 (0.58) | DRD2HRH4CHRM1DRD3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10010615-B2 | Amino acid conjugates of quetiapine, process for making and using the same | KEMPHARM, INC. (US) | 2018-07-03 | — | — | US | disclosed |
| US-20170246308-A1 | Amino Acid Conjugates of Quetiapine, Process for Making and Using the Same | ALTER DOMUS (US) LLC | 2017-08-31 | — | — | US | disclosed |
| US-20170246307-A1 | Amino Acid Conjugates of Quetiapine, Process for Making and Using the Same | ALTER DOMUS (US) LLC | 2017-08-31 | — | — | US | disclosed |
| US-20170209586-A1 | AMINO ACID CONJUGATES OF QUETIAPINE, PROCESS FOR MAKING AND USING THE SAME | ALTER DOMUS (US) LLC | 2017-07-27 | — | — | US | disclosed |
| US-9597403-B2 | Amino acid conjugates of quetiapine, process for making and using the same | KEMPHARM, INC. (US) | 2017-03-21 | — | — | US | disclosed |
| EP-2987789-A1 | AMINO ACID CONJUGATES OF QUETIAPINE, PROCESS FOR MAKING AND USING THE SAME | Kempharm, Inc. (US) | 2016-02-24 | — | — | EP | disclosed |
| EP-2519101-B1 | AMINO ACID CONJUGATES OF QUETIAPINE, PROCESS FOR MAKING AND USING THE SAME | KEMPHARM INC (US) | 2015-08-19 | — | — | EP | disclosed |
| US-20140287050-A1 | AMINO ACID CONJUGATES OF QUETIAPINE, PROCESS FOR MAKING AND USING THE SAME | KEMPHARM, INC. (US) | 2014-09-25 | — | — | US | disclosed |
| US-8715699-B2 | Amino acid conjugates of quetiapine, process for making and using the same | KEMPHARM, INC. (US) | 2014-05-06 | — | — | US | disclosed |
| US-20120276168-A1 | AMINO ACID CONJUGATES OF QUETIAPINE, PROCESS FOR MAKING AND USING THE SAME | ALTER DOMUS (US) LLC | 2012-11-01 | — | — | US | disclosed |
| US-20110183963-A1 | Amino Acid Conjugates of Quetiapine, Process for Making and Using the Same | ALTER DOMUS (US) LLC | 2011-07-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170246307-A1 | Amino Acid Conjugates of Quetiapine, Process for Making and Using the Same | QPCT, SLC1A5, SLC1A2 | DRD2 159/4885HRH4 945/4885CHRM1 800/4885 |
| US-20170209586-A1 | AMINO ACID CONJUGATES OF QUETIAPINE, PROCESS FOR MAKING AND USING THE SAME | QPCT, AADAT, SLC1A5 | DRD2 224/4885HRH4 1021/4885CHRM1 788/4885 |
| US-20170246308-A1 | Amino Acid Conjugates of Quetiapine, Process for Making and Using the Same | QPCT, SLC1A5, SLC1A2 | DRD2 159/4885HRH4 945/4885CHRM1 800/4885 |
| US-20110183963-A1 | Amino Acid Conjugates of Quetiapine, Process for Making and Using the Same | QPCT, SLC1A5, SLC1A2 | DRD2 176/4885HRH4 1090/4885CHRM1 958/4885 |
| US-20120276168-A1 | AMINO ACID CONJUGATES OF QUETIAPINE, PROCESS FOR MAKING AND USING THE SAME | SLC1A5, QPCT, SLC6A15 | DRD2 152/4885HRH4 1146/4885CHRM1 1306/4885 |
| US-20140287050-A1 | AMINO ACID CONJUGATES OF QUETIAPINE, PROCESS FOR MAKING AND USING THE SAME | QPCT, SLC1A5, SLC1A2 | DRD2 176/4885HRH4 1090/4885CHRM1 958/4885 |
| US-10010615-B2 | Amino acid conjugates of quetiapine, process for making and using the same | QPCT, SLC1A5, SLC1A2 | DRD2 159/4885HRH4 945/4885CHRM1 800/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.