Sugi Predict

Sugi Predict / Compounds / SCHEMBL2159792

SCHEMBL2159792

SCHEMBL2159792

Cc1ccccc1OCCCNC(=O)[C@@H]1C[C@H](C)CC[C@H]1C(C)C

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TRPM8 Q7Z2W7 4/20 0.47
▸ ALDH1A1 P00352 4/20 0.47
▸ KDM4E B2RXH2 2/20 0.47
▸ KMT2A Q03164 4/20 0.45
▸ HTT P42858 2/20 0.45
▸ MEN1 O00255 2/20 0.45
▸ MAPT P10636 2/20 0.45
▸ APAF1 O14727 1/20 0.45
▸ MITF O75030 1/20 0.45
▸ XBP1 P17861 1/20 0.45
▸ MAPK1 P28482 1/20 0.45
▸ SMN1; SMN2 Q16637 1/20 0.45
▸ NPSR1 Q6W5P4 1/20 0.45
▸ TDP1 Q9NUW8 2/20 0.44
▸ DRD2 P14416 2/20 0.41
▸ DRD4 P21917 2/20 0.41
▸ SSTR4 P31391 1/20 0.41
▸ TP53 P04637 1/20 0.40
▸ DRD3 P35462 1/20 0.40
▸ EPHX1 P07099 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2159809 0.90 KMT2A (0.54) TRPM8ALDH1A1KMT2AEPHX1
SCHEMBL2159887 0.83 NPC1 (0.53) TRPM8KMT2AMEN1SMN1; SMN2EPHX1
SCHEMBL2160155 0.82 TRPM8 (0.50) TRPM8ALDH1A1KDM4EKMT2AMEN1
SCHEMBL24540436 0.82 TRPM8 (0.44) TRPM8ALDH1A1KMT2AEPHX1
SCHEMBL24540470 0.82 TRPM8 (0.44) TRPM8ALDH1A1KMT2AEPHX1
SCHEMBL24540639 0.81 MTNR1A (0.46) TRPM8ALDH1A1KDM4EKMT2A
SCHEMBL24540761 0.81 TRPM8 (0.44) TRPM8ALDH1A1KMT2AEPHX1
SCHEMBL2628622 0.81 TRPM8 (0.48) TRPM8MAPTTP53EPHX1
SCHEMBL24540387 0.81 TRPM8 (0.48) TRPM8MAPTTP53EPHX1
SCHEMBL24540361 0.80 TRPM8 (0.44) TRPM8ALDH1A1KMT2AEPHX1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8377422-B2 Carboxamide derivatives having cooling properties GIVAUDAN S.A. (CH) 2013-02-19 — — US claimed
US-20110182833-A1 Carboxamide Derivatives Having Cooling Properties GIVAUDAN SA (CH) 2011-07-28 — — US claimed
EP-2229352-A2 CARBOXAMIDE DERIVATIVES HAVING COOLING PROPERTIES Givaudan SA (CH) 2010-09-22 — — EP claimed
WO-2009070910-A2 CARBOXAMIDE DERIVATIEVES HAVING COOLING PROPERTIES GIVAUDAN SA (CH) 2009-06-11 — — WO claimed
US-8377422-B2 Carboxamide derivatives having cooling properties GIVAUDAN S.A. (CH) 2013-02-19 — — US disclosed
US-20110182833-A1 Carboxamide Derivatives Having Cooling Properties GIVAUDAN SA (CH) 2011-07-28 — — US disclosed
EP-2229352-A2 CARBOXAMIDE DERIVATIVES HAVING COOLING PROPERTIES Givaudan SA (CH) 2010-09-22 — — EP disclosed
WO-2009070910-A2 CARBOXAMIDE DERIVATIEVES HAVING COOLING PROPERTIES GIVAUDAN SA (CH) 2009-06-11 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110182833-A1 Carboxamide Derivatives Having Cooling Properties CPS1, NQO2, NDUFA2 TRPM8 376/4885ALDH1A1 237/4885KDM4E 1236/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.