Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 3/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2160079 | 0.70 | TRPA1 (0.31) | TRPA1 | |
| SCHEMBL66594 | 0.70 | TSHR (0.35) | TRPA1LMNATSHR | |
| SCHEMBL1436102 | 0.70 | TRPA1 (0.31) | TRPA1 | |
| SCHEMBL612799 | 0.67 | MAPT (0.39) | TRPA1LMNATSHR | |
| SCHEMBL10434951 | 0.67 | MAPT (0.39) | TRPA1LMNATSHR | |
| SCHEMBL1435667 | 0.67 | IDO1 (0.35) | LMNA | |
| SCHEMBL7424947 | 0.65 | — | — | |
| SCHEMBL16835462 | 0.65 | — | — | |
| SCHEMBL67783 | 0.65 | — | — | |
| SCHEMBL5602389 | 0.65 | TP53 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2670738-A2 | 1,4 OXAZINES AS BACE1 AND/OR BACE2 INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2013-12-11 | — | — | EP | disclosed |
| US-8399459-B2 | 1,4 oxazines as BACE1 and/or BACE2 inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2013-03-19 | — | — | US | disclosed |
| WO-2012104263-A2 | 1,4 OXAZINES AS BACE1 AND/OR BACE2 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-08-09 | — | — | WO | disclosed |
| US-20120196863-A1 | 1,4 OXAZINES AS BACE1 AND/OR BACE2 INHIBITORS | SIENA BIOTECH S.P.A. (IT) | 2012-08-02 | — | — | US | disclosed |
| US-20110190122-A1 | Triazole and Imidazole Compounds, Use Thereof and Agents Containing Them | BASF SE (DE) | 2011-08-04 | — | — | US | disclosed |
| US-20110183842-A1 | Triazole and Imidazole Compounds, Use Thereof and Agents Containing Them | BASF SE (DE) | 2011-07-28 | — | — | US | disclosed |
| US-20110166020-A1 | Imidazole and Triazole Compounds, Use Thereof and Agents Containing Said Compounds | BASF SE (DE) | 2011-07-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120196863-A1 | 1,4 OXAZINES AS BACE1 AND/OR BACE2 INHIBITORS | BACE2, BACE1, PSEN1 | TRPA1 3442/4885LMNA 3323/4885TSHR 4807/4885 |
| US-20110190122-A1 | Triazole and Imidazole Compounds, Use Thereof and Agents Containing Them | ABAT, OAT, TYR | TRPA1 1751/4885LMNA 3379/4885TSHR 2880/4885 |
| US-20110183842-A1 | Triazole and Imidazole Compounds, Use Thereof and Agents Containing Them | OAT, ABAT, TYR | TRPA1 1923/4885LMNA 3515/4885TSHR 2401/4885 |
| US-20110166020-A1 | Imidazole and Triazole Compounds, Use Thereof and Agents Containing Said Compounds | COX4I1, NISCH, TPMT | TRPA1 1932/4885LMNA 3141/4885TSHR 3564/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.