Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | POLB | P06746 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ELANE | P08246 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | EDNRB | P24530 | 1/20 | 0.33 |
| ▸ | EDNRA | P25101 | 1/20 | 0.33 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | TOP1 | P11387 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28159474 | 0.72 | EDNRB (0.43) | ALDH1A1POLBGAAKDM4EHPGD | |
| SCHEMBL28246631 | 0.71 | EDNRB (0.44) | ALDH1A1POLBGAAKDM4EHPGD | |
| SCHEMBL6095770 | 0.69 | MEN1 (0.43) | ALDH1A1POLBGAAKDM4EHPGD | |
| SCHEMBL28559637 | 0.69 | ALDH1A1 (0.41) | ALDH1A1POLBGAAKDM4EHPGD | |
| SCHEMBL30825174 | 0.69 | MEN1 (0.43) | ALDH1A1POLBGAAKDM4EHPGD | |
| SCHEMBL29241693 | 0.66 | ALDH1A1 (0.38) | ALDH1A1POLBGAAKDM4EHPGD | |
| SCHEMBL22181785 | 0.64 | ELANE (0.34) | ELANEEPHX2NPC1HCAR2 | |
| SCHEMBL21598447 | 0.64 | NOTUM (0.42) | ALDH1A1LMNARAB9ANPC1PKM | |
| SCHEMBL30681424 | 0.63 | MEN1 (0.39) | ALDH1A1POLBKDM4EHPGDMEN1 | |
| SCHEMBL19410707 | 0.62 | ALDH1A1 (0.43) | ALDH1A1POLBHPGDMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3807266-A1 | PYRAZOLE DERIVATIVES AS MALT1 INHIBITORS | Janssen Pharmaceutica N.V. (BE) | 2021-04-21 | — | — | EP | disclosed |
| WO-2019243964-A1 | PYRAZOLE DERIVATIVES AS MALT1 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2019-12-26 | — | — | WO | disclosed |