Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | HTR3A | P46098 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | APAF1 | O14727 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | STAT3 | P40763 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10129360 | 0.80 | CYP19A1 (0.51) | MEN1KMT2APOLBSMN1; SMN2HSD17B10 | |
| SCHEMBL11623258 | 0.75 | ALDH1A1 (0.45) | POLBSMN1; SMN2CNR2HSD17B10ALOX15 | |
| SCHEMBL19818489 | 0.75 | ALDH1A1 (0.39) | KMT2APOLBHSD17B10ALDH1A1CYP19A1 | |
| SCHEMBL11624688 | 0.75 | CNR2 (0.50) | POLBSMN1; SMN2CNR2HSD17B10ALDH1A1 | |
| SCHEMBL11974276 | 0.75 | ALDH1A1 (0.59) | MEN1KMT2APOLBSMN1; SMN2CNR2 | |
| SCHEMBL17170689 | 0.75 | TSHR (0.67) | MEN1KMT2APOLBHTR3ASMN1; SMN2 | |
| SCHEMBL24358819 | 0.74 | CNR2 (0.50) | CNR2HSD17B10ALDH1A1KDM4EGAA | |
| SCHEMBL21600843 | 0.73 | CNR2 (0.52) | POLBCNR2HSD17B10ALDH1A1KDM4E | |
| SCHEMBL11712972 | 0.72 | MEN1 (0.45) | MEN1KMT2APOLBSMN1; SMN2CNR2 | |
| SCHEMBL17176648 | 0.72 | RAB9A (0.64) | MEN1KMT2APOLBHTR3ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019242689-A1 | CYANO-SUBSTITUTED PYRIDINE AND CYANO-SUBSTITUTED PYRIMIDINE COMPOUND, AND PREPARATION METHOD AND APPLICATION THEREOF | 北京赛特明强医药科技有限公司 | 2019-12-26 | — | — | WO | disclosed |