Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 6/20 | 0.47 |
| ▸ | JAK3 | P52333 | 3/20 | 0.47 |
| ▸ | FLT3 | P36888 | 3/20 | 0.47 |
| ▸ | BTK | Q06187 | 3/20 | 0.47 |
| ▸ | KDR | P35968 | 3/20 | 0.47 |
| ▸ | CDK7 | P50613 | 2/20 | 0.47 |
| ▸ | IGF1R | P08069 | 2/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | PAK4 | O96013 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
| ▸ | FYN | P06241 | 1/20 | 0.47 |
| ▸ | CSF1R | P07333 | 1/20 | 0.47 |
| ▸ | RET | P07949 | 1/20 | 0.47 |
| ▸ | PIM1 | P11309 | 1/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.47 |
| ▸ | PRKACA | P17612 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30380016 | 0.88 | CDK7 (0.59) | FGFR1JAK3FLT3BTKKDR | |
| SCHEMBL21600869 | 0.88 | CDK7 (0.59) | FGFR1JAK3FLT3BTKKDR | |
| SCHEMBL28537296 | 0.86 | FLT3 (0.49) | FGFR1JAK3FLT3BTKKDR | |
| SCHEMBL30379427 | 0.86 | FLT3 (0.49) | FGFR1JAK3FLT3BTKKDR | |
| SCHEMBL21601040 | 0.85 | EGFR (0.47) | FGFR1JAK3BTKKDREGFR | |
| SCHEMBL21596397 | 0.85 | EGFR (0.49) | FGFR1JAK3BTKKDRIGF1R | |
| SCHEMBL28546954 | 0.84 | EGFR (0.48) | FGFR1JAK3BTKEGFRFGFR4 | |
| SCHEMBL21600800 | 0.82 | JAK3 (0.48) | FGFR1JAK3BTKIGF1REGFR | |
| SCHEMBL21600798 | 0.82 | EGFR (0.51) | FGFR1JAK3FLT3KDRCDK7 | |
| SCHEMBL30379569 | 0.82 | EGFR (0.51) | FGFR1JAK3FLT3KDRCDK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112313207-B | Cyano-substituted pyridine and cyano-substituted pyrimidine compounds, and preparation methods and applications thereof | 北京赛特明强医药科技有限公司 | 2023-02-14 | — | — | CN | disclosed |
| CN-112313207-A | Cyano-substituted pyridine and cyano-substituted pyrimidine compounds, and preparation methods and applications thereof | 北京赛特明强医药科技有限公司 | 2021-02-02 | — | — | CN | disclosed |