Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 9/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.39 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.38 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.37 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 2/20 | 0.36 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.35 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21600802 | 0.90 | MAPK10 (0.40) | FGFR4MAPK10FGFR1FGFR2FGFR3 | |
| SCHEMBL21601007 | 0.88 | FGFR1 (0.52) | FGFR4FGFR1FGFR2FGFR3MAPK3 | |
| SCHEMBL21600884 | 0.83 | MAPK10 (0.45) | FGFR4MAPK10FGFR1FGFR2FGFR3 | |
| SCHEMBL21600833 | 0.81 | MAPK10 (0.42) | FGFR4MAPK10FGFR1CHEK1MAPK3 | |
| SCHEMBL28539793 | 0.81 | FGFR4 (0.45) | FGFR4FGFR1FGFR2FGFR3MAPK3 | |
| SCHEMBL21600988 | 0.80 | MAPK10 (0.46) | FGFR4MAPK10FGFR1FGFR2FGFR3 | |
| SCHEMBL21600944 | 0.79 | MAPK10 (0.41) | FGFR4MAPK10FGFR1FGFR2FGFR3 | |
| SCHEMBL21600948 | 0.79 | FGFR4 (0.39) | FGFR4MAPK10FGFR1FGFR2FGFR3 | |
| SCHEMBL21599131 | 0.79 | MAPK10 (0.44) | MAPK10CHEK1MAPK3 | |
| SCHEMBL30379621 | 0.79 | MAPK10 (0.44) | MAPK10CHEK1MAPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019242689-A1 | CYANO-SUBSTITUTED PYRIDINE AND CYANO-SUBSTITUTED PYRIMIDINE COMPOUND, AND PREPARATION METHOD AND APPLICATION THEREOF | 北京赛特明强医药科技有限公司 | 2019-12-26 | — | — | WO | disclosed |