Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 9/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 8/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.38 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.38 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 2/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.35 |
| ▸ | WEE1 | P30291 | 2/20 | 0.35 |
| ▸ | JAK3 | P52333 | 2/20 | 0.35 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | PAK4 | O96013 | 1/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | FYN | P06241 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21596402 | 0.89 | FGFR1 (0.49) | FGFR4FGFR1FGFR2FGFR3MAPK3 | |
| SCHEMBL21600884 | 0.84 | MAPK10 (0.45) | FGFR4FGFR1MAPK10FGFR2FGFR3 | |
| SCHEMBL21600944 | 0.83 | MAPK10 (0.41) | FGFR4FGFR1MAPK10FGFR2FGFR3 | |
| SCHEMBL21600802 | 0.82 | MAPK10 (0.40) | FGFR4FGFR1MAPK10FGFR2FGFR3 | |
| SCHEMBL21600811 | 0.81 | MAPK10 (0.42) | FGFR4FGFR1MAPK10FGFR2FGFR3 | |
| SCHEMBL21596334 | 0.80 | FGFR1 (0.50) | FGFR4FGFR1FGFR2FGFR3MAPK3 | |
| SCHEMBL21596373 | 0.80 | MAPK3 (0.47) | FGFR4FGFR1FGFR2FGFR3MAPK3 | |
| SCHEMBL21600988 | 0.80 | MAPK10 (0.46) | FGFR4FGFR1MAPK10FGFR2FGFR3 | |
| SCHEMBL21600935 | 0.79 | FGFR4 (0.42) | FGFR4FGFR1MAPK10FGFR2FGFR3 | |
| SCHEMBL21600829 | 0.78 | MAPK3 (0.46) | FGFR1MAPK3RETWEE1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112313207-B | Cyano-substituted pyridine and cyano-substituted pyrimidine compounds, and preparation methods and applications thereof | 北京赛特明强医药科技有限公司 | 2023-02-14 | — | — | CN | disclosed |
| CN-112313207-A | Cyano-substituted pyridine and cyano-substituted pyrimidine compounds, and preparation methods and applications thereof | 北京赛特明强医药科技有限公司 | 2021-02-02 | — | — | CN | disclosed |
| WO-2019242689-A1 | CYANO-SUBSTITUTED PYRIDINE AND CYANO-SUBSTITUTED PYRIMIDINE COMPOUND, AND PREPARATION METHOD AND APPLICATION THEREOF | 北京赛特明强医药科技有限公司 | 2019-12-26 | — | — | WO | disclosed |