Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | FGFR4 | P22455 | 6/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.38 |
| ▸ | HTR6 | P50406 | 2/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.36 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.36 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.35 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.35 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.35 |
| ▸ | JAK3 | P52333 | 2/20 | 0.34 |
| ▸ | STAT6 | P42226 | 1/20 | 0.34 |
| ▸ | MET | P08581 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | PAK4 | O96013 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21600947 | 0.88 | FGFR4 (0.48) | MAPK10FGFR4FGFR1FGFR2FGFR3 | |
| SCHEMBL21600884 | 0.87 | MAPK10 (0.45) | MAPK10FGFR4FGFR1FGFR2FGFR3 | |
| SCHEMBL21600811 | 0.86 | MAPK10 (0.42) | MAPK10FGFR4FGFR1FGFR2FGFR3 | |
| SCHEMBL21600948 | 0.83 | FGFR4 (0.39) | MAPK10FGFR4FGFR1FGFR2FGFR3 | |
| SCHEMBL21600802 | 0.82 | MAPK10 (0.40) | MAPK10FGFR4FGFR1FGFR2FGFR3 | |
| SCHEMBL21596325 | 0.82 | FGFR4 (0.42) | MAPK10FGFR4FGFR1HTR6HTR2A | |
| SCHEMBL21600988 | 0.81 | MAPK10 (0.46) | MAPK10FGFR4FGFR1FGFR2FGFR3 | |
| SCHEMBL21600935 | 0.79 | FGFR4 (0.42) | MAPK10FGFR4FGFR1FGFR2FGFR3 | |
| SCHEMBL21596386 | 0.79 | FGFR1 (0.50) | MAPK10FGFR4FGFR1FGFR2FGFR3 | |
| SCHEMBL21596360 | 0.78 | PRKCQ (0.38) | MAPK10PRKCQPRKCDCHEK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019242689-A1 | CYANO-SUBSTITUTED PYRIDINE AND CYANO-SUBSTITUTED PYRIMIDINE COMPOUND, AND PREPARATION METHOD AND APPLICATION THEREOF | 北京赛特明强医药科技有限公司 | 2019-12-26 | — | — | WO | disclosed |