Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 2/20 | 0.64 |
| ▸ | SRC | P12931 | 12/20 | 0.60 |
| ▸ | MAP3K7 | O43318 | 10/20 | 0.60 |
| ▸ | FGFR1 | P11362 | 7/20 | 0.60 |
| ▸ | MAP2K1 | Q02750 | 4/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.60 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.58 |
| ▸ | EGFR | P00533 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21600950 | 0.89 | JAK3 (0.55) | JAK3SRCMAP3K7FGFR1MAP2K1 | |
| SCHEMBL21601021 | 0.89 | MAP3K7 (0.59) | JAK3SRCMAP3K7FGFR1MAP2K1 | |
| SCHEMBL21600951 | 0.87 | EGFR (0.57) | JAK3SRCMAP3K7FGFR1MAP2K1 | |
| SCHEMBL21600914 | 0.87 | JAK3 (0.54) | JAK3SRCMAP3K7FGFR1MAP2K1 | |
| SCHEMBL23581207 | 0.84 | JAK3 (0.61) | JAK3SRCMAP3K7FGFR1MAP2K1 | |
| SCHEMBL28540649 | 0.84 | SLC2A1 (0.66) | JAK3SLC2A1EGFR | |
| SCHEMBL30378896 | 0.84 | SLC2A1 (0.66) | JAK3SLC2A1EGFR | |
| SCHEMBL21600966 | 0.83 | JAK3 (0.57) | JAK3SRCMAP3K7FGFR1MAP2K1 | |
| SCHEMBL21600787 | 0.83 | SLC2A1 (0.60) | JAK3FGFR1MAP2K1SLC2A1EGFR | |
| SCHEMBL21600974 | 0.83 | CTSC (0.52) | JAK3SRCMAP3K7FGFR1MAP2K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112313207-B | Cyano-substituted pyridine and cyano-substituted pyrimidine compounds, and preparation methods and applications thereof | 北京赛特明强医药科技有限公司 | 2023-02-14 | — | — | CN | disclosed |
| CN-112313207-A | Cyano-substituted pyridine and cyano-substituted pyrimidine compounds, and preparation methods and applications thereof | 北京赛特明强医药科技有限公司 | 2021-02-02 | — | — | CN | disclosed |
| WO-2019242689-A1 | CYANO-SUBSTITUTED PYRIDINE AND CYANO-SUBSTITUTED PYRIMIDINE COMPOUND, AND PREPARATION METHOD AND APPLICATION THEREOF | 北京赛特明强医药科技有限公司 | 2019-12-26 | — | — | WO | disclosed |
| WO-2019242689-A1 | CYANO-SUBSTITUTED PYRIDINE AND CYANO-SUBSTITUTED PYRIMIDINE COMPOUND, AND PREPARATION METHOD AND APPLICATION THEREOF | 北京赛特明强医药科技有限公司 | 2019-12-26 | — | — | WO | disclosed |