Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 13/20 | 0.54 |
| ▸ | HTR6 | P50406 | 2/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 3/20 | 0.48 |
| ▸ | JAK1 | P23458 | 3/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | TTK | P33981 | 1/20 | 0.45 |
| ▸ | FLT3 | P36888 | 1/20 | 0.45 |
| ▸ | TXK | P42681 | 1/20 | 0.45 |
| ▸ | BLK | P51451 | 1/20 | 0.45 |
| ▸ | BTK | Q06187 | 1/20 | 0.45 |
| ▸ | ITK | Q08881 | 1/20 | 0.45 |
| ▸ | CTSC | P53634 | 1/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.43 |
| ▸ | TYK2 | P29597 | 1/20 | 0.43 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21600898 | 0.93 | FGFR4 (0.47) | JAK3HTR6HTR2AJAK2EGFR | |
| SCHEMBL21601014 | 0.89 | JAK3 (0.52) | JAK3HTR6HTR2AJAK2JAK1 | |
| SCHEMBL21600964 | 0.88 | JAK3 (0.60) | JAK3HTR6HTR2AJAK2JAK1 | |
| SCHEMBL21600973 | 0.87 | JAK3 (0.55) | JAK3HTR6HTR2AJAK2JAK1 | |
| SCHEMBL21600970 | 0.87 | JAK3 (0.55) | JAK3HTR6HTR2AJAK2JAK1 | |
| SCHEMBL21601024 | 0.86 | JAK3 (0.51) | JAK3HTR6HTR2AJAK2JAK1 | |
| SCHEMBL21600899 | 0.85 | FGFR1 (0.49) | JAK3HTR6HTR2AJAK2JAK1 | |
| SCHEMBL21601025 | 0.85 | FGFR4 (0.51) | JAK3JAK2JAK1FGFR1FGFR2 | |
| SCHEMBL21600955 | 0.83 | JAK3 (0.47) | JAK3HTR6HTR2AJAK2JAK1 | |
| SCHEMBL21600974 | 0.83 | CTSC (0.52) | JAK3JAK2EGFRFLT3BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019242689-A1 | CYANO-SUBSTITUTED PYRIDINE AND CYANO-SUBSTITUTED PYRIMIDINE COMPOUND, AND PREPARATION METHOD AND APPLICATION THEREOF | 北京赛特明强医药科技有限公司 | 2019-12-26 | — | — | WO | disclosed |