Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSC | P53634 | 2/20 | 0.52 |
| ▸ | JAK3 | P52333 | 2/20 | 0.52 |
| ▸ | MAP3K7 | O43318 | 11/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.51 |
| ▸ | SRC | P12931 | 6/20 | 0.51 |
| ▸ | MAP2K1 | Q02750 | 6/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.51 |
| ▸ | BTK | Q06187 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 2/20 | 0.47 |
| ▸ | FLT3 | P36888 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21600963 | 0.92 | MAP3K7 (0.50) | CTSCJAK3MAP3K7FGFR1SRC | |
| SCHEMBL21600886 | 0.91 | FGFR4 (0.53) | CTSCJAK3MAP3K7FGFR1SRC | |
| SCHEMBL21600958 | 0.85 | JAK3 (0.49) | CTSCJAK3MAP3K7FGFR1EGFR | |
| SCHEMBL21596364 | 0.85 | CTSC (0.47) | CTSCJAK3MAP3K7FGFR1EGFR | |
| SCHEMBL30380067 | 0.85 | CTSC (0.47) | CTSCJAK3MAP3K7FGFR1EGFR | |
| SCHEMBL21601024 | 0.84 | JAK3 (0.51) | CTSCJAK3MAP3K7FGFR1BTK | |
| SCHEMBL21601014 | 0.83 | JAK3 (0.52) | CTSCJAK3MAP3K7FGFR1SRC | |
| SCHEMBL21600954 | 0.83 | JAK3 (0.54) | CTSCJAK3MAP3K7FGFR1BTK | |
| SCHEMBL21596307 | 0.83 | JAK3 (0.64) | JAK3MAP3K7FGFR1SRCMAP2K1 | |
| SCHEMBL21596386 | 0.82 | FGFR1 (0.50) | CTSCJAK3FGFR1BTKEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019242689-A1 | CYANO-SUBSTITUTED PYRIDINE AND CYANO-SUBSTITUTED PYRIMIDINE COMPOUND, AND PREPARATION METHOD AND APPLICATION THEREOF | 北京赛特明强医药科技有限公司 | 2019-12-26 | — | — | WO | disclosed |