Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K7 | O43318 | 9/20 | 0.50 |
| ▸ | CTSC | P53634 | 2/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.48 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.48 |
| ▸ | MAP2K1 | Q02750 | 7/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.47 |
| ▸ | SRC | P12931 | 4/20 | 0.47 |
| ▸ | JAK3 | P52333 | 3/20 | 0.47 |
| ▸ | JAK1 | P23458 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | TEC | P42680 | 1/20 | 0.45 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.45 |
| ▸ | FLT3 | P36888 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21600974 | 0.92 | CTSC (0.52) | MAP3K7CTSCFGFR1MAP2K1MAPK1 | |
| SCHEMBL21601021 | 0.87 | MAP3K7 (0.59) | MAP3K7FGFR1MAP2K1MAPK1SRC | |
| SCHEMBL21600955 | 0.86 | JAK3 (0.47) | MAP3K7CTSCFGFR1FGFR2JAK3 | |
| SCHEMBL21600958 | 0.84 | JAK3 (0.49) | MAP3K7CTSCFGFR1FGFR2JAK3 | |
| SCHEMBL21601024 | 0.84 | JAK3 (0.51) | MAP3K7CTSCFGFR1FGFR2JAK3 | |
| SCHEMBL21600969 | 0.83 | JAK3 (0.53) | CTSCFGFR1FGFR2JAK3JAK1 | |
| SCHEMBL21600886 | 0.83 | FGFR4 (0.53) | MAP3K7CTSCFGFR1FGFR2MAP2K1 | |
| SCHEMBL30380067 | 0.83 | CTSC (0.47) | MAP3K7CTSCFGFR1FGFR2JAK3 | |
| SCHEMBL21596364 | 0.83 | CTSC (0.47) | MAP3K7CTSCFGFR1FGFR2JAK3 | |
| SCHEMBL21601014 | 0.82 | JAK3 (0.52) | MAP3K7CTSCFGFR1FGFR2SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019242689-A1 | CYANO-SUBSTITUTED PYRIDINE AND CYANO-SUBSTITUTED PYRIMIDINE COMPOUND, AND PREPARATION METHOD AND APPLICATION THEREOF | 北京赛特明强医药科技有限公司 | 2019-12-26 | — | — | WO | disclosed |