Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 1/20 | 0.49 |
| ▸ | CTSC | P53634 | 6/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.47 |
| ▸ | MAPK3 | P27361 | 5/20 | 0.46 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.45 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.45 |
| ▸ | CTSL | P07711 | 2/20 | 0.43 |
| ▸ | CTSB | P07858 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 3/20 | 0.43 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30380067 | 0.98 | CTSC (0.47) | JAK3CTSCFGFR1MAPK3MAP3K7 | |
| SCHEMBL21596364 | 0.98 | CTSC (0.47) | JAK3CTSCFGFR1MAPK3MAP3K7 | |
| SCHEMBL21596399 | 0.89 | FGFR4 (0.51) | JAK3FGFR1MAPK3FGFR2EGFR | |
| SCHEMBL30379371 | 0.89 | FGFR4 (0.51) | JAK3FGFR1MAPK3FGFR2EGFR | |
| SCHEMBL21600965 | 0.87 | JAK3 (0.60) | JAK3FGFR1MAPK3MAP3K7EGFR | |
| SCHEMBL21600974 | 0.85 | CTSC (0.52) | JAK3CTSCFGFR1MAP3K7EGFR | |
| SCHEMBL21600911 | 0.85 | FGFR4 (0.50) | JAK3FGFR1MAPK3FGFR2FGFR4 | |
| SCHEMBL21600959 | 0.84 | JAK3 (0.58) | JAK3FGFR1MAPK3MAP3K7EGFR | |
| SCHEMBL21600833 | 0.84 | MAPK10 (0.42) | JAK3CTSCFGFR1MAPK3CTSL | |
| SCHEMBL21600963 | 0.84 | MAP3K7 (0.50) | JAK3CTSCFGFR1MAP3K7FGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019242689-A1 | CYANO-SUBSTITUTED PYRIDINE AND CYANO-SUBSTITUTED PYRIMIDINE COMPOUND, AND PREPARATION METHOD AND APPLICATION THEREOF | 北京赛特明强医药科技有限公司 | 2019-12-26 | — | — | WO | disclosed |