Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 2/20 | 0.47 |
| ▸ | MAPK3 | P27361 | 9/20 | 0.44 |
| ▸ | FGFR4 | P22455 | 6/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21600976 | 0.86 | JAK3 (0.49) | JAK3MAPK3FGFR4LRRK2EGFR | |
| SCHEMBL21600965 | 0.82 | JAK3 (0.60) | JAK3MAPK3FGFR4EGFR | |
| SCHEMBL21600959 | 0.80 | JAK3 (0.58) | JAK3MAPK3FGFR4EGFR | |
| SCHEMBL21596347 | 0.76 | PLK1 (0.56) | JAK3MAPK3FGFR4EGFR | |
| SCHEMBL21600908 | 0.76 | JAK3 (0.51) | JAK3MAPK3FGFR4EGFR | |
| SCHEMBL21596311 | 0.72 | MAPK3 (0.46) | JAK3MAPK3 | |
| SCHEMBL21601022 | 0.72 | JAK3 (0.68) | JAK3MAPK3FGFR4EGFR | |
| SCHEMBL30379344 | 0.71 | MAPK3 (0.54) | JAK3MAPK3FGFR4EGFR | |
| SCHEMBL21596335 | 0.70 | MAPK3 (0.54) | MAPK3FGFR4 | |
| SCHEMBL21596327 | 0.70 | EGFR (0.62) | JAK3EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019242689-A1 | CYANO-SUBSTITUTED PYRIDINE AND CYANO-SUBSTITUTED PYRIMIDINE COMPOUND, AND PREPARATION METHOD AND APPLICATION THEREOF | 北京赛特明强医药科技有限公司 | 2019-12-26 | — | — | WO | disclosed |