Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ARG1 | P05089 | 9/20 | 0.36 |
| ▸ | ARG2 | P78540 | 8/20 | 0.36 |
| ▸ | ODC1 | P11926 | 1/20 | 0.32 |
| ▸ | FDPS | P14324 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.31 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1301385 | 0.81 | CYP1A2 (0.41) | CYP1A2MEN1ALDH1A1THRBKMT2A | |
| SCHEMBL348479 | 0.79 | MEN1 (0.54) | CYP1A2MEN1ALDH1A1THRBKMT2A | |
| SCHEMBL20054900 | 0.77 | — | — | |
| SCHEMBL24163861 | 0.74 | MEN1 (0.68) | CYP1A2MEN1ALDH1A1THRBKMT2A | |
| SCHEMBL6759254 | 0.74 | MEN1 (0.68) | CYP1A2MEN1ALDH1A1THRBKMT2A | |
| SCHEMBL6759253 | 0.74 | MEN1 (0.68) | CYP1A2MEN1ALDH1A1THRBKMT2A | |
| SCHEMBL28308308 | 0.74 | MEN1 (0.42) | CYP1A2MEN1ALDH1A1THRBKMT2A | |
| SCHEMBL4344392 | 0.74 | GGT1 (0.41) | CYP1A2MEN1ALDH1A1THRBKMT2A | |
| SCHEMBL27620509 | 0.74 | GGT1 (0.41) | CYP1A2MEN1ALDH1A1THRBKMT2A | |
| SCHEMBL7281147 | 0.74 | GGT1 (0.41) | CYP1A2MEN1ALDH1A1THRBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019245890-A1 | ARGINASE INHIBITORS AND METHODS OF USE | MERCK SHARP & DOHME CORP. (US) | 2019-12-26 | — | — | WO | disclosed |