Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 13/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.36 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.36 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.36 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.36 |
| ▸ | KDR | P35968 | 3/20 | 0.36 |
| ▸ | FLT3 | P36888 | 2/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21602899 | 0.93 | TTK (0.40) | TTKFGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL21602951 | 0.86 | TTK (0.40) | TTKFGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL21602966 | 0.86 | FGFR1 (0.39) | TTKFGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL21602938 | 0.86 | TTK (0.43) | TTKFGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL21602855 | 0.84 | TTK (0.47) | TTKLRRK2FGFR1FGFR2FGFR4 | |
| SCHEMBL21252298 | 0.83 | TTK (0.38) | TTKKDR | |
| SCHEMBL21602893 | 0.82 | TTK (0.48) | TTKFGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL21602967 | 0.81 | TRPM8 (0.39) | TTKFGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL21602941 | 0.80 | TTK (0.38) | TTKFGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL21602928 | 0.79 | MAP4K1 (0.46) | TTKFGFR1FGFR2FGFR4FGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019242587-A1 | HIGHLY SELECTIVE FGFR I INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF | 上海和誉生物医药科技有限公司 | 2019-12-26 | — | — | WO | disclosed |