Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 6/20 | 0.47 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.43 |
| ▸ | GAK | O14976 | 2/20 | 0.42 |
| ▸ | MTOR | P42345 | 3/20 | 0.40 |
| ▸ | PIM1 | P11309 | 2/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.37 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.37 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21602938 | 0.92 | TTK (0.43) | TTKCCNA2CDK2MAP4K1FGFR1 | |
| SCHEMBL21602939 | 0.89 | TTK (0.47) | TTKTRPM8GAKPIM1LRRK2 | |
| SCHEMBL21602968 | 0.87 | TRPM8 (0.60) | TRPM8GAKMTOR | |
| SCHEMBL21602944 | 0.87 | FGFR1 (0.39) | TTKTRPM8GAKMTORFGFR1 | |
| SCHEMBL21602905 | 0.86 | TRPM8 (0.40) | TTKTRPM8GAKMTORLRRK2 | |
| SCHEMBL21602941 | 0.86 | TTK (0.38) | TTKCCNA2CDK2MAP4K1FGFR1 | |
| SCHEMBL21602893 | 0.85 | TTK (0.48) | TTKCCNA2CDK2MAP4K1FGFR1 | |
| SCHEMBL21602913 | 0.85 | TRPM8 (0.43) | TRPM8GAKMTORFGFR3 | |
| SCHEMBL21602948 | 0.85 | TRPM8 (0.43) | TRPM8GAKMTORLRRK2MAP4K1 | |
| SCHEMBL21602899 | 0.85 | TTK (0.40) | TTKMAP4K1FGFR1FGFR2FGFR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111936493-B | High-selectivity FGFri inhibitor and preparation method and application thereof | 上海和誉生物医药科技有限公司 | 2023-05-26 | — | — | CN | disclosed |
| WO-2019242587-A1 | HIGHLY SELECTIVE FGFR I INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF | 上海和誉生物医药科技有限公司 | 2019-12-26 | — | — | WO | disclosed |