Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 6/20 | 0.39 |
| ▸ | FGFR3 | P22607 | 5/20 | 0.39 |
| ▸ | KDR | P35968 | 5/20 | 0.39 |
| ▸ | TTK | P33981 | 3/20 | 0.39 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.38 |
| ▸ | GAK | O14976 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | FGFR2 | P21802 | 4/20 | 0.37 |
| ▸ | FGFR4 | P22455 | 4/20 | 0.37 |
| ▸ | FLT3 | P36888 | 2/20 | 0.37 |
| ▸ | CSF1R | P07333 | 1/20 | 0.37 |
| ▸ | KIT | P10721 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21602855 | 0.87 | TTK (0.47) | FGFR1FGFR3KDRTTKTRPM8 | |
| SCHEMBL21602957 | 0.82 | JAK2 (0.37) | FGFR1FGFR3TTKTRPM8GAK | |
| SCHEMBL21602968 | 0.81 | TRPM8 (0.60) | TRPM8GAKPIK3CAMTOR | |
| SCHEMBL21602956 | 0.80 | GAK (0.37) | FGFR1FGFR3TTKTRPM8GAK | |
| SCHEMBL21602948 | 0.80 | TRPM8 (0.43) | TRPM8GAKPIK3CAMTOR | |
| SCHEMBL21602913 | 0.80 | TRPM8 (0.43) | FGFR3TRPM8GAKMTOR | |
| SCHEMBL21602921 | 0.79 | FGFR1 (0.45) | FGFR1TTKTRPM8GAKPIK3CD | |
| SCHEMBL21602945 | 0.79 | TRPM8 (0.42) | FGFR3TRPM8GAKPIK3CAMTOR | |
| SCHEMBL21602938 | 0.79 | TTK (0.43) | FGFR1FGFR3KDRTTKPIK3CD | |
| SCHEMBL21602839 | 0.78 | PIK3CA (0.48) | TRPM8GAKPIK3CAMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019242587-A1 | HIGHLY SELECTIVE FGFR I INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF | 上海和誉生物医药科技有限公司 | 2019-12-26 | — | — | WO | disclosed |