Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 13/20 | 0.42 |
| ▸ | RAB9A | P51151 | 9/20 | 0.41 |
| ▸ | NPC1 | O15118 | 8/20 | 0.41 |
| ▸ | POLB | P06746 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | PKM | P14618 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | PRNP | P04156 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 6/20 | 0.40 |
| ▸ | TP53 | P04637 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | DAO | P14920 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27415414 | 0.81 | ALDH1A1 (0.49) | ALDH1A1RAB9ANPC1MEN1KMT2A | |
| SCHEMBL8291574 | 0.80 | NPC1 (0.47) | ALDH1A1RAB9ANPC1POLBMEN1 | |
| SCHEMBL21604092 | 0.76 | ALDH1A1 (0.39) | ALDH1A1RAB9ANPC1POLBMEN1 | |
| SCHEMBL27415416 | 0.75 | NPC1 (0.32) | ALDH1A1RAB9ANPC1CYP1A2CYP2C19 | |
| SCHEMBL11883278 | 0.74 | ALDH1A1 (0.51) | ALDH1A1RAB9ANPC1POLBMEN1 | |
| SCHEMBL6246731 | 0.74 | ALDH1A1 (0.51) | ALDH1A1RAB9ANPC1POLBMEN1 | |
| SCHEMBL27415413 | 0.73 | EPHX2 (0.36) | RAB9ANPC1KMT2ANFKB1NFKB2 | |
| SCHEMBL30554632 | 0.71 | ALDH1A1 (0.46) | ALDH1A1RAB9ANPC1POLBMEN1 | |
| SCHEMBL30554642 | 0.71 | DAO (0.50) | ALDH1A1RAB9ANPC1POLBMEN1 | |
| SCHEMBL30554624 | 0.71 | DAO (0.46) | ALDH1A1RAB9ANPC1POLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019243550-A1 | THIOPHENE DERIVATIVES FOR THE TREATMENT OF DISORDERS CAUSED BY IGE | UCB Biopharma SRL (BE) | 2019-12-26 | — | — | WO | disclosed |