Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.47 |
| ▸ | POLB | P06746 | 4/20 | 0.47 |
| ▸ | PKM | P14618 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 5/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 6/20 | 0.46 |
| ▸ | NPC1 | O15118 | 5/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.44 |
| ▸ | RELA | Q04206 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6246731 | 0.97 | ALDH1A1 (0.51) | DAOALDH1A1POLBPKMHPGD | |
| SCHEMBL30554623 | 0.82 | DAO (0.46) | DAOALDH1A1POLBPKMHPGD | |
| SCHEMBL11883278 | 0.79 | ALDH1A1 (0.51) | DAOALDH1A1POLBPKMHPGD | |
| SCHEMBL13832492 | 0.79 | PNMT (0.48) | PKMGAAALOX15HSD17B10 | |
| SCHEMBL30554624 | 0.79 | DAO (0.46) | DAOALDH1A1POLBPKMHPGD | |
| SCHEMBL15409702 | 0.79 | ALDH1A1 (0.47) | DAOALDH1A1POLBPKMHPGD | |
| SCHEMBL30554626 | 0.78 | DAO (0.45) | DAOALDH1A1POLBPKMHPGD | |
| SCHEMBL17545266 | 0.78 | PNMT (0.61) | PKMGAAALOX15HSD17B10 | |
| SCHEMBL29601184 | 0.76 | DAO (0.44) | DAOALDH1A1POLBPKMHPGD | |
| SCHEMBL20852601 | 0.76 | PRMT5 (0.41) | PKMGAAALOX15HSD17B10CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3612180-B1 | SUBSTITUTED 2-ACYLAMINO-CYCLOALKYLTHIOPHENE-3-CARBOXYLIC ACID ARYLAMIDES AS INHIBITORS OF CALCIUM-ACTIVATED CHLORIDE CHANNEL TMEM16A | UNIV CALIFORNIA (US) | 2023-10-11 | — | — | EP | claimed |