Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
| ▸ | RORC | P51449 | 3/20 | 0.37 |
| ▸ | CA12 | O43570 | 7/20 | 0.36 |
| ▸ | CA1 | P00915 | 7/20 | 0.36 |
| ▸ | CA2 | P00918 | 7/20 | 0.36 |
| ▸ | CA9 | Q16790 | 7/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21605621 | 1.00 | HCRTR2 (0.38) | HCRTR2EPHX1RORCCA12CA1 | |
| SCHEMBL21607412 | 0.88 | HCRTR2 (0.39) | HCRTR2EPHX1RORCMEN1ALDH1A1 | |
| SCHEMBL21605550 | 0.88 | HCRTR2 (0.39) | HCRTR2EPHX1RORCMEN1ALDH1A1 | |
| SCHEMBL25568145 | 0.83 | HCRTR2 (0.41) | HCRTR2EPHX1CA12CA1CA2 | |
| SCHEMBL25568142 | 0.81 | HCRTR2 (0.42) | HCRTR2EPHX1CA12CA1CA2 | |
| SCHEMBL25568141 | 0.81 | HCRTR2 (0.42) | HCRTR2EPHX1CA12CA1CA2 | |
| SCHEMBL15497076 | 0.81 | HCRTR2 (0.44) | HCRTR2EPHX1CA12CA1CA2 | |
| SCHEMBL23189782 | 0.78 | RORC (0.35) | RORC | |
| SCHEMBL23189781 | 0.78 | RORC (0.35) | RORC | |
| SCHEMBL28519612 | 0.78 | HCRTR2 (0.43) | HCRTR2EPHX1CA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3807261-B1 | PYRIDINYL PYRAZOLES AS MODULATORS OF RORYT | JANSSEN PHARMACEUTICA NV (BE) | 2022-07-13 | — | — | EP | disclosed |
| EP-3807261-B1 | PYRIDINYL PYRAZOLES AS MODULATORS OF RORYT | JANSSEN PHARMACEUTICA NV (BE) | 2022-07-13 | — | — | EP | disclosed |
| CN-112292373-A | Pyridylpyrazoles as modulators of ROR γ t | 詹森药业有限公司 | 2021-01-29 | — | — | CN | disclosed |
| WO-2019243999-A1 | PHENYL SUBSTITUTED PYRAZOLES AS MODULATORS OF RORYT | JANSSEN PHARMACEUTICA NV (BE) | 2019-12-26 | — | — | WO | disclosed |
| WO-2019244002-A1 | PYRIDINYL PYRAZOLES AS MODULATORS OF RORYT | JANSSEN PHARMACEUTICA NV (BE) | 2019-12-26 | — | — | WO | disclosed |