Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 14/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21605550 | 1.00 | HCRTR2 (0.39) | HCRTR2RORCEPHX1MEN1ALDH1A1 | |
| SCHEMBL21605621 | 0.88 | HCRTR2 (0.38) | HCRTR2RORCEPHX1MEN1ALDH1A1 | |
| SCHEMBL21605705 | 0.88 | HCRTR2 (0.38) | HCRTR2RORCEPHX1MEN1ALDH1A1 | |
| SCHEMBL23220061 | 0.86 | HCRTR2 (0.41) | HCRTR2EPHX1MEN1ALDH1A1TSHR | |
| SCHEMBL21606419 | 0.86 | HCRTR2 (0.41) | HCRTR2EPHX1MEN1ALDH1A1TSHR | |
| SCHEMBL21606423 | 0.84 | SLC6A9 (0.39) | HCRTR2RORCEPHX1MEN1ALDH1A1 | |
| SCHEMBL23219989 | 0.83 | HCRTR2 (0.37) | HCRTR2EPHX1MEN1ALDH1A1TSHR | |
| SCHEMBL21606412 | 0.83 | HCRTR2 (0.37) | HCRTR2EPHX1MEN1ALDH1A1TSHR | |
| SCHEMBL24463788 | 0.83 | HCRTR2 (0.37) | HCRTR2EPHX1MEN1ALDH1A1TSHR | |
| SCHEMBL25568142 | 0.82 | HCRTR2 (0.42) | HCRTR2EPHX1MEN1ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3807261-B1 | PYRIDINYL PYRAZOLES AS MODULATORS OF RORYT | JANSSEN PHARMACEUTICA NV (BE) | 2022-07-13 | — | — | EP | disclosed |
| US-11345666-B2 | Phenyl and pyridinyl substituted imidazoles as modulators of RORγT | JANSSEN PHARMACEUTICA NV (BE) | 2022-05-31 | — | — | US | disclosed |
| US-11034658-B2 | Pyridinyl pyrazoles as modulators of RORγT | JANSSEN PHARMACEUTICA NV (BE) | 2021-06-15 | — | — | US | disclosed |
| US-10975057-B2 | 6-aminopyridin-3-yl pyrazoles as modulators of RORgT | JANSSEN PHARMACEUTICA NV (BE) | 2021-04-13 | — | — | US | disclosed |
| US-10975037-B2 | Phenyl substituted pyrazoles as modulators of RORγt | JANSSEN PHARMACEUTICA NV (BE) | 2021-04-13 | — | — | US | disclosed |
| CN-112566901-A | Phenyl-substituted pyrazoles as modulators of ROR γ t | 詹森药业有限公司 | 2021-03-26 | — | — | CN | disclosed |
| CN-112334450-A | Phenyl and pyridyl substituted imidazoles as modulators of ROR γ t | 詹森药业有限公司 | 2021-02-05 | — | — | CN | disclosed |
| CN-112292373-A | Pyridylpyrazoles as modulators of ROR γ t | 詹森药业有限公司 | 2021-01-29 | — | — | CN | disclosed |
| CN-112292183-A | 6-aminopyridin-3-yl-pyrazoles as modulators of ROR γ t | 詹森药业有限公司 | 2021-01-29 | — | — | CN | disclosed |
| WO-2019243999-A1 | PHENYL SUBSTITUTED PYRAZOLES AS MODULATORS OF RORYT | JANSSEN PHARMACEUTICA NV (BE) | 2019-12-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11034658-B2 | Pyridinyl pyrazoles as modulators of RORγT | RORC, RORB, RORA | HCRTR2 1183/4885RORC 1/4885EPHX1 1351/4885 |
| US-10975037-B2 | Phenyl substituted pyrazoles as modulators of RORγt | RORC, RORB, RORA | HCRTR2 981/4885RORC 1/4885EPHX1 1753/4885 |
| US-11345666-B2 | Phenyl and pyridinyl substituted imidazoles as modulators of RORγT | RORC, RORB, RORA | HCRTR2 1092/4885RORC 1/4885EPHX1 1149/4885 |
| US-10975057-B2 | 6-aminopyridin-3-yl pyrazoles as modulators of RORgT | RORC, RORA, RORB | HCRTR2 1187/4885RORC 1/4885EPHX1 1504/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.