SCHEMBL2160666

SCHEMBL2160666

Cc1cc(Br)cc(C2OCCO2)c1

nearest known ligand 0.35

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 1/20 0.35
ALDH1A1 P00352 1/20 0.31
MAPK1 P28482 1/20 0.31
ESR1 P03372 1/20 0.31
NR3C1 P04150 1/20 0.31
PGR P06401 1/20 0.31
AR P10275 1/20 0.31
ESR2 Q92731 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3564666 0.85 CCNB2 (0.31)
SCHEMBL31367048 0.77 RAB9A (0.31) RAB9A
SCHEMBL13262184 0.77 HPGD (0.34) RAB9AALDH1A1
SCHEMBL3574837 0.76 DRD3 (0.33)
SCHEMBL6208359 0.76
SCHEMBL601887 0.76 GAA (0.30)
SCHEMBL23802251 0.76 ALDH1A1 (0.34) ALDH1A1
SCHEMBL15459089 0.75 EDNRB (0.31) ALDH1A1
SCHEMBL30169612 0.72 HTR2C (0.37) ALDH1A1MAPK1
SCHEMBL16955827 0.72 HTR2C (0.37) ALDH1A1MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108047025-B Preparation method of 3-aldehyde-5-methylbenzoic acid 珠海奥博凯生物医药技术有限公司 2020-08-04 CN claimed
EP-3218341-B1 PHENYL BASED COMPOUNDS SUBSTITUTED WITH ALDEHYDE MOIETIES AND THEIR USE IN PERFUMERY GIVAUDAN SA (CH) 2024-05-01 EP disclosed
US-RE49502-E1 Phenyl based compounds substituted with aldehyde moieties and their use in perfumery GIVAUDAN SA (CH) 2023-04-25 US disclosed
CN-107074713-B Phenyl-based compounds substituted with aldehyde moieties and their use in perfumery 奇华顿股份有限公司 2021-03-26 CN disclosed
CN-108047025-B Preparation method of 3-aldehyde-5-methylbenzoic acid 珠海奥博凯生物医药技术有限公司 2020-08-04 CN disclosed
US-10443018-B2 Phenyl based compounds substituted with aldehyde moieties and their use in perfumery GIVAUDAN S.A. (CH) 2019-10-15 US disclosed
US-20170298291-A1 Phenyl Based Compounds Substituted with Aldehyde Moieties and their Use in Perfumery GIVAUDAN S.A. (CH) 2017-10-19 US disclosed
US-20170298291-A1 Phenyl Based Compounds Substituted with Aldehyde Moieties and their Use in Perfumery GIVAUDAN S.A. (CH) 2017-10-19 US disclosed
US-20170298291-A1 Phenyl Based Compounds Substituted with Aldehyde Moieties and their Use in Perfumery GIVAUDAN S.A. (CH) 2017-10-19 US disclosed
EP-3218341-A1 PHENYL BASED COMPOUNDS SUBSTITUTED WITH ALDEHYDE MOIETIES AND THEIR USE IN PERFUMERY Givaudan S.A. (CH) 2017-09-20 EP disclosed
WO-2017117538-A1 META-AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS PAN INTEGRIN ANTAGONISTS SAINT LOUIS UNIVERSITY (US) 2017-07-06 WO disclosed
WO-2016074865-A1 PHENYL BASED COMPOUNDS SUBSTITUTED WITH ALDEHYDE MOIETIES AND THEIR USE IN PERFUMERY GIVAUDAN SA (CH) 2016-05-19 WO disclosed
WO-2016074865-A1 PHENYL BASED COMPOUNDS SUBSTITUTED WITH ALDEHYDE MOIETIES AND THEIR USE IN PERFUMERY GIVAUDAN SA (CH) 2016-05-19 WO disclosed
WO-2016074118-A1 IMPROVEMENTS IN OR RELATING TO ORGANIC COMPOUNDS GIVAUDAN SA (CH) 2016-05-19 WO disclosed
US-9085606-B2 Beta amino acid derivatives as integrin antagonists SAINT LOUIS UNIVERSITY (US) 2015-07-21 US disclosed
US-20140038910-A1 Beta Amino Acid Derivatives as Integrin Antagonists SAINT LOUIS UNIVERSITY (US) 2014-02-06 US disclosed
US-20110184029-A1 PYRIDONE DERIVATIVES AS NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 2011-07-28 US disclosed
US-20110184029-A1 PYRIDONE DERIVATIVES AS NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 2011-07-28 US disclosed
US-20110184029-A1 PYRIDONE DERIVATIVES AS NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 2011-07-28 US disclosed
WO-2010009047-A1 PYRIDONE DERIVATIVES AS NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 2010-01-21 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140038910-A1 Beta Amino Acid Derivatives as Integrin Antagonists ITGB2, ITGAL, ITGB1 RAB9A 861/4885ALDH1A1 919/4885MAPK1 1584/4885
US-20110184029-A1 PYRIDONE DERIVATIVES AS NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS DPYD, TYMP, PNPO RAB9A 4274/4885ALDH1A1 460/4885MAPK1 1543/4885
US-10443018-B2 Phenyl based compounds substituted with aldehyde moieties and their use in perfumery C5, C9, CBR3 RAB9A 4288/4885ALDH1A1 245/4885MAPK1 1632/4885
US-20170298291-A1 Phenyl Based Compounds Substituted with Aldehyde Moieties and their Use in Perfumery C5, C9, CBR3 RAB9A 4288/4885ALDH1A1 245/4885MAPK1 1632/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.