Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A2 | O15244 | 17/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.62 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.62 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19137975 | 1.00 | SLC22A2 (0.62) | SLC22A2CYP3A4TMEM97ABCG2 | |
| SCHEMBL29775453 | 1.00 | SLC22A2 (0.62) | SLC22A2CYP3A4TMEM97ABCG2 | |
| SCHEMBL80839 | 1.00 | SLC22A2 (0.62) | SLC22A2CYP3A4TMEM97ABCG2 | |
| SCHEMBL29391507 | 1.00 | SLC22A2 (0.62) | SLC22A2CYP3A4TMEM97ABCG2 | |
| SCHEMBL17072299 | 1.00 | SLC22A2 (0.62) | SLC22A2CYP3A4TMEM97ABCG2 | |
| SCHEMBL81877 | 1.00 | SLC22A2 (0.62) | SLC22A2CYP3A4TMEM97ABCG2 | |
| SCHEMBL9943501 | 1.00 | SLC22A2 (0.62) | SLC22A2CYP3A4TMEM97ABCG2 | |
| SCHEMBL18854204 | 0.93 | SLC22A2 (0.74) | SLC22A2CYP3A4TMEM97ABCG2 | |
| SCHEMBL18854377 | 0.93 | SLC22A2 (0.74) | SLC22A2CYP3A4TMEM97ABCG2 | |
| SCHEMBL2302444 | 0.93 | SLC22A2 (0.74) | SLC22A2CYP3A4TMEM97ABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9707246-B2 | Substituted (3S,11AR)-N-[(2,4-difluorophenyl)methyl]-6-oxy-3-methyl-5,7-dioxo-2,3,5,7,11,11A-hexahydro[1,3]oxazolo[3,2-A]pyrido[1,2-D]pyrazine-8-carboxamides as HIV agents | SHIONOGI & CO., LTD. (JP) | 2017-07-18 | — | — | US | disclosed |
| US-9707246-B2 | Substituted (3S,11AR)-N-[(2,4-difluorophenyl)methyl]-6-oxy-3-methyl-5,7-dioxo-2,3,5,7,11,11A-hexahydro[1,3]oxazolo[3,2-A]pyrido[1,2-D]pyrazine-8-carboxamides as HIV agents | SHIONOGI & CO., LTD. (JP) | 2017-07-18 | — | — | US | disclosed |
| EP-2660239-B1 | CHEMICAL COMPOUNDS AS SYNTHETIC INTERMEDIATES | VIIV HEALTHCARE CO (US) | 2016-11-23 | — | — | EP | disclosed |
| EP-2320909-B1 | CHEMICAL COMPOUNDS | VIIV HEALTHCARE CO (US) | 2016-01-06 | — | — | EP | disclosed |
| US-20150335667-A1 | CHEMICAL COMPOUNDS | SHIONOGI & CO (JP) | 2015-11-26 | — | — | US | disclosed |
| US-20150183803-A1 | (3S,11aR)-6-[(PHENYLMETHYL)OXY]-3-METHYL-2,3,11,11a-TETRAHYDROOXAZOLO[3,2-a]PYRIDO[1,2-d]PYRAZINE-5,7-DIONE OF THE FORMULA P-9 AND/OR (3S,11aR)-6-[(PHENYLMETHYL)OXY]-8-BROMO-3-METHYL-2,3,11,11a-TETRAHYDROOXAZOLO[3,2-a]PYRIDO[1,2-d]PYRAZINE-5,7-DIONE OF THE FORMULA P-10 | SHIONOGI & CO (JP) | 2015-07-02 | — | — | US | disclosed |
| US-9012650-B2 | Substituted (3S, 11aR)-N-[(2,4-difluorophenyl)methyl]-6-oxy-3-methyl-5,7-dioxo-2,3,5,7,11,11a-hexahydro[1,3]oxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-carboxamides of formula (I) useful as HIV agents | SHIONOGI & CO., LTD. (JP) | 2015-04-21 | — | — | US | disclosed |
| US-8981129-B2 | 2-(2-hydroxy-2-phenylethyl)-3-[(phenylmethyl)oxy]-4H-pyran-4-one of the formula P-3 and/or 2-[(E)-2-phenylethenyl]-3-[(phenylmethyl)oxy]-4H-Pyran-4-one of the formula P-4 | SHIONOGI & CO., LTD. (JP) | 2015-03-17 | — | — | US | disclosed |
| US-8940912-B2 | 4-oxo-3-[(phenylmethyl)oxy]-4H-pyran-2-carboxylic acid | VIIV HEALTHCARE COMPANY (US) | 2015-01-27 | — | — | US | disclosed |
| US-20140256679-A1 | CHEMICAL COMPOUNDS | SHIONOGI & CO., LTD. (JP) | 2014-09-11 | — | — | US | disclosed |
| US-20140256961-A1 | CHEMICAL COMPOUNDS | SHIONOGI & CO., LTD. (JP) | 2014-09-11 | — | — | US | disclosed |
| US-8765965-B2 | 1-(2,3-dihydroxypropyl)-4-oxo-3-[(phenylmethyl)oxy]-1,4-dihydro-2-pyridinecarboxylic acid of the formula P-6 and/or methyl 1-(2,3-dihydroxypropyl)-4-oxo-3-[(phenylmethyl)oxy]-1,4-dihydro-2-pyridinecarboxylate of the formula P-7 | SHIONOGI & CO., LTD. (JP) | 2014-07-01 | — | — | US | disclosed |
| US-20140039207-A1 | CHEMICAL COMPOUNDS | SHIONOGI & CO., LTD. (JP) | 2014-02-06 | — | — | US | disclosed |
| US-20140031555-A1 | CHEMICAL COMPOUNDS | SHIONOGI & CO., LTD. (JP) | 2014-01-30 | — | — | US | disclosed |
| US-8580967-B2 | Methyl 3-(benzyloxy)-1-(2,2-dihydroxyethyl)-4-oxo-1,4-dihydropyridine-2-carboxylate and processes for the preparation thereof | SHIONOGI & CO., LTD. (JP) | 2013-11-12 | — | — | US | disclosed |
| US-20110183940-A1 | CHEMICAL COMPOUNDS | VIIV HEALTHCARE COMPANY | 2011-07-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140256679-A1 | CHEMICAL COMPOUNDS | PAICS, APRT, SAMHD1 | SLC22A2 2264/4885CYP3A4 98/4885TMEM97 4144/4885 |
| US-20140256961-A1 | CHEMICAL COMPOUNDS | PAICS, APRT, SAMHD1 | SLC22A2 2264/4885CYP3A4 98/4885TMEM97 4144/4885 |
| US-20150183803-A1 | (3S,11aR)-6-[(PHENYLMETHYL)OXY]-3-METHYL-2,3,11,11a-TETRAHYDROOXAZOLO[3,2-a]PYRIDO[1,2-d]PYRAZINE-5,7-DIONE OF THE FORMULA P-9 AND/OR (3S,11aR)-6-[(PHENYLMETHYL)OXY]-8-BROMO-3-METHYL-2,3,11,11a-TETRAHYDROOXAZOLO[3,2-a]PYRIDO[1,2-d]PYRAZINE-5,7-DIONE OF THE FORMULA P-10 | CDK9, INTS9, DPYD | SLC22A2 3477/4885CYP3A4 403/4885TMEM97 2455/4885 |
| US-20150335667-A1 | CHEMICAL COMPOUNDS | PAICS, APRT, SAMHD1 | SLC22A2 2264/4885CYP3A4 98/4885TMEM97 4144/4885 |
| US-20140039207-A1 | CHEMICAL COMPOUNDS | PAICS, APRT, SAMHD1 | SLC22A2 2264/4885CYP3A4 98/4885TMEM97 4144/4885 |
| US-20110183940-A1 | CHEMICAL COMPOUNDS | PAICS, APRT, SAMHD1 | SLC22A2 2264/4885CYP3A4 98/4885TMEM97 4144/4885 |
| US-20140031555-A1 | CHEMICAL COMPOUNDS | PAICS, APRT, SAMHD1 | SLC22A2 2264/4885CYP3A4 98/4885TMEM97 4144/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.