Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | GRM5 | P41594 | 2/20 | 0.46 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.46 |
| ▸ | DTYMK | P23919 | 1/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM1B | Q8NB78 | 1/20 | 0.41 |
| ▸ | CCNK | O75909 | 1/20 | 0.41 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.41 |
| ▸ | SQOR | Q9Y6N5 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21608350 | 0.80 | POLB (0.47) | POLBGRM5GRM1DTYMKGPR119 | |
| SCHEMBL9933273 | 0.79 | POLB (0.53) | POLBDTYMKGPR119CHRM2CHRM4 | |
| SCHEMBL12836021 | 0.79 | POLB (0.53) | POLBDTYMKGPR119CHRM2CHRM4 | |
| SCHEMBL21607887 | 0.79 | POLB (0.47) | POLBDTYMKGPR119CHRM2CHRM4 | |
| SCHEMBL21607916 | 0.77 | GPR119 (0.59) | POLBGPR119CHRM2CHRM4CHRM1 | |
| SCHEMBL20818170 | 0.76 | POLB (0.52) | POLBDTYMKGPR119CHRM2CHRM4 | |
| SCHEMBL21608123 | 0.76 | KDM1A (0.43) | POLBGPR119CHRM2CHRM4CHRM1 | |
| SCHEMBL20818805 | 0.76 | POLB (0.49) | POLBDTYMKGPR119CHRM2CHRM4 | |
| SCHEMBL30476371 | 0.76 | POLB (0.49) | POLBDTYMKGPR119CHRM2CHRM4 | |
| SCHEMBL21607904 | 0.76 | ALOX5AP (0.53) | POLBGPR119KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019243531-A1 | OGA INHIBITOR COMPOUNDS | JANSSEN PHARMACEUTICA NV (BE) | 2019-12-26 | — | — | WO | disclosed |