Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 5/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24275808 | 0.77 | SYK (0.38) | SYKNFKB1NFKB2RELALMNA | |
| SCHEMBL24275860 | 0.74 | GAA (0.40) | SYKNFKB1NFKB2RELALMNA | |
| SCHEMBL28720076 | 0.73 | IDO1 (0.45) | IDO1LMNAMAPTSMN1; SMN2NPC1 | |
| SCHEMBL4735920 | 0.72 | CYP3A4 (0.41) | SYKLMNAMAPTSMN1; SMN2NPC1 | |
| SCHEMBL15052607 | 0.72 | ALDH1A1 (0.38) | SYKNFKB1NFKB2RELAMAPT | |
| SCHEMBL465766 | 0.71 | SYK (0.47) | SYKLMNAESR1MAPTSMN1; SMN2 | |
| SCHEMBL20077493 | 0.71 | NTRK1 (0.46) | NFKB1NFKB2RELAMAPTSMN1; SMN2 | |
| SCHEMBL998243 | 0.70 | IDO1 (0.43) | IDO1LMNASMN1; SMN2NPC1RAB9A | |
| SCHEMBL28616856 | 0.70 | IDO1 (0.47) | IDO1LMNAMAPTSMN1; SMN2NPC1 | |
| SCHEMBL1979899 | 0.70 | CSNK1D (0.49) | IDO1LMNAMAPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022053010-A1 | FUSED RING PYRIMIDONE DERIVATIVES FOR USE IN THE TREATMENT OF HBV INFECTION OR OF HBV-INDUCED DISEASES | Janssen Sciences Ireland Unlimited Company (IE) | 2022-03-17 | — | — | WO | disclosed |
| WO-2019243531-A1 | OGA INHIBITOR COMPOUNDS | JANSSEN PHARMACEUTICA NV (BE) | 2019-12-26 | — | — | WO | disclosed |