Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 2/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.38 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | PPARD | Q03181 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | NQO2 | P16083 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8859133 | 0.83 | PPARG (0.52) | ACHEMAPTCYP3A4PPARGPPARD | |
| SCHEMBL12062531 | 0.82 | SLC6A2 (0.43) | SLC6A2SLC6A4SLC6A3ACHEMAPT | |
| SCHEMBL11244312 | 0.81 | SLC6A2 (0.43) | SLC6A2SLC6A4SLC6A3ACHECYP3A4 | |
| SCHEMBL13304652 | 0.81 | SLC6A2 (0.45) | SLC6A2SLC6A4SLC6A3ACHEMAPT | |
| SCHEMBL801219 | 0.81 | HDAC4 (0.48) | SLC6A2SLC6A4SLC6A3ACHEMAPT | |
| SCHEMBL6846328 | 0.80 | ALDH1A1 (0.37) | MAPTTAS1R3TAS1R1ALDH1A1TSHR | |
| SCHEMBL13413339 | 0.79 | SLC6A2 (0.44) | SLC6A2SLC6A4SLC6A3ACHEMAPT | |
| SCHEMBL5592068 | 0.79 | SLC6A2 (0.48) | SLC6A2SLC6A4SLC6A3ACHEMAPT | |
| SCHEMBL31135381 | 0.79 | SLC6A2 (0.44) | SLC6A2SLC6A4SLC6A3ACHEMAPT | |
| SCHEMBL4774742 | 0.78 | ALDH1A1 (0.47) | MAPTCYP2D6ALDH1A1LMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8524893-B2 | Process for the preparation of temsirolimus and its intermediates | FRESENIUS KABI ONCOLOGY LIMITED (IN) | 2013-09-03 | — | — | US | disclosed |
| US-8524893-B2 | Process for the preparation of temsirolimus and its intermediates | FRESENIUS KABI ONCOLOGY LIMITED (IN) | 2013-09-03 | — | — | US | disclosed |
| EP-2528906-A2 | PROCESS FOR THE PREPARATION OF TEMSIROLIMUS AND ITS INTERMEDIATES | Fresenius Kabi Oncology Ltd (IN) | 2012-12-05 | — | — | EP | disclosed |
| WO-2011092564-A2 | PROCESS FOR THE PREPARATION OF TEMSIROLIMUS AND ITS INTERMEDIATES | FRESENIUS KABI ONCOLOGY LTD (IN) | 2011-08-04 | — | — | WO | disclosed |
| WO-2011092564-A2 | PROCESS FOR THE PREPARATION OF TEMSIROLIMUS AND ITS INTERMEDIATES | FRESENIUS KABI ONCOLOGY LTD (IN) | 2011-08-04 | — | — | WO | disclosed |
| US-20110184167-A1 | PROCESS FOR THE PREPARATION OF TEMSIROLIMUS AND ITS INTERMEDIATES | FRESENIUS KABI ONCOLOGY LIMITED (IN) | 2011-07-28 | — | — | US | disclosed |
| US-20110184167-A1 | PROCESS FOR THE PREPARATION OF TEMSIROLIMUS AND ITS INTERMEDIATES | FRESENIUS KABI ONCOLOGY LIMITED (IN) | 2011-07-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110184167-A1 | PROCESS FOR THE PREPARATION OF TEMSIROLIMUS AND ITS INTERMEDIATES | RICTOR, MTOR, MAPKAP1 | SLC6A2 4767/4885SLC6A4 4732/4885SLC6A3 4816/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.