SCHEMBL21609189

SCHEMBL21609189

COc1cccc(OC)c1[S+]([O-])Nc1noc2cc(-c3ccncc3)cc(OC)c12

nearest known ligand 0.41

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
KAT6A Q92794 15/20 0.41
KAT7 O95251 14/20 0.41
KAT6B Q8WYB5 7/20 0.41
KAT5 Q92993 4/20 0.41
KAT8 Q9H7Z6 4/20 0.41
KCNA5 P22460 1/20 0.36
SGMS1 Q86VZ5 1/20 0.36
SGMS2 Q8NHU3 1/20 0.36
SMN1; SMN2 Q16637 2/20 0.36
TP53 P04637 1/20 0.36
RAB9A P51151 1/20 0.36
NPC1 O15118 1/20 0.36
MAPT P10636 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21609265 0.83 ERN1 (0.38) KAT6AKAT7KAT6BKAT5KAT8
SCHEMBL21609073 0.82 KAT6A (0.40) KAT6AKAT7KAT6BKAT5KAT8
SCHEMBL21609190 0.79 KAT6A (0.41) KAT6AKAT7KAT6BKAT5KAT8
SCHEMBL21641939 0.77 KAT6A (0.66) KAT6AKAT7KAT6BKAT5KAT8
SCHEMBL25564467 0.76 KAT6A (0.42) KAT6AKAT7KAT6BKAT5KAT8
SCHEMBL22817457 0.76 KAT6A (0.68) KAT6AKAT7KAT6BKAT5KAT8
SCHEMBL26804388 0.76 KAT7 (0.68) KAT6AKAT7KAT6BKAT5KAT8
SCHEMBL22817409 0.76 KAT6A (0.67) KAT6AKAT7KAT6BKAT5KAT8
SCHEMBL22817319 0.75 KAT7 (0.68) KAT6AKAT7KAT6BKAT5KAT8
SCHEMBL22817404 0.74 KAT6A (0.51) KAT6AKAT7KAT6BKAT5KAT8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3810602-B1 COMPOUNDS CTXT PTY LTD (AU) 2023-11-01 EP disclosed
WO-2019243491-A1 COMPOUNDS CTXT PTY LIMITED (AU) 2019-12-26 WO disclosed