Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 6/20 | 0.52 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.52 |
| ▸ | MAOA | P21397 | 1/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.52 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.52 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.52 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.52 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.45 |
| ▸ | ANPEP | P15144 | 1/20 | 0.44 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.44 |
| ▸ | DNPEP | Q9ULA0 | 1/20 | 0.44 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.44 |
| ▸ | CACNA2D1 | P54289 | 2/20 | 0.42 |
| ▸ | CACNB3 | P54284 | 1/20 | 0.42 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.42 |
| ▸ | PGR | P06401 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21610477 | 1.00 | TAAR1 (0.52) | TAAR1SLC6A2SIGMAR1MAOASLC6A4 | |
| SCHEMBL21610472 | 1.00 | TAAR1 (0.52) | TAAR1SLC6A2SIGMAR1MAOASLC6A4 | |
| SCHEMBL6563096 | 0.83 | EPHX1 (0.56) | TAAR1SLC6A2SIGMAR1MAOASLC6A4 | |
| SCHEMBL516032 | 0.83 | EPHX1 (0.56) | TAAR1SLC6A2SIGMAR1MAOASLC6A4 | |
| SCHEMBL28916127 | 0.80 | TRPA1 (0.57) | TAAR1SLC6A2SIGMAR1MAOASLC6A4 | |
| SCHEMBL28915633 | 0.80 | TRPA1 (0.57) | TAAR1SLC6A2SIGMAR1MAOASLC6A4 | |
| SCHEMBL4588322 | 0.79 | TAAR1 (0.50) | TAAR1SLC6A2SIGMAR1MAOASLC6A4 | |
| SCHEMBL2604897 | 0.79 | TAAR1 (0.50) | TAAR1SLC6A2SIGMAR1MAOASLC6A4 | |
| SCHEMBL21610466 | 0.79 | PNMT (0.62) | TAAR1 | |
| SCHEMBL21610464 | 0.79 | PNMT (0.62) | TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210246169-A1 | COMPOUNDS | SPERO THERAPEUTICS, INC. (US) | 2021-08-12 | — | — | US | disclosed |
| WO-2020002325-A1 | COMPOUNDS | SPERO THERAPEUTICS, INC. (US) | 2020-01-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210246169-A1 | COMPOUNDS | MRPS18A, MRPL37, MRPS35 | TAAR1 1982/4885SLC6A2 4635/4885SIGMAR1 142/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.