Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RRM2 | P31350 | 2/20 | 0.45 |
| ▸ | RRM1 | P23921 | 1/20 | 0.45 |
| ▸ | RRM2B | Q7LG56 | 1/20 | 0.45 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.45 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.37 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.35 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.35 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.35 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.35 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.34 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Urea SCHEMBL28153660 | 0.95 | RRM2 (0.49) | RRM2RRM1RRM2BCISD1NAPRT | |
| Urea SCHEMBL21612150 | 0.91 | RRM2 (0.46) | RRM2RRM1RRM2BCISD1NAPRT | |
| SCHEMBL1501696 | 0.87 | — | — | |
| Thiourea SCHEMBL28502228 | 0.86 | RRM2 (0.55) | RRM2RRM1RRM2BCISD1NAPRT | |
| Hydrogen Sulfide SCHEMBL28281811 | 0.85 | RRM1 (0.45) | RRM2RRM1RRM2BCISD1NAPRT | |
| Thiosemicarbazide SCHEMBL27702929 | 0.80 | RRM2 (0.57) | RRM2RRM1RRM2BCISD1HDAC3 | |
| Trifluoroacetic Acid SCHEMBL3213348 | 0.80 | HTT (0.40) | RRM2RRM1RRM2BCISD1NAPRT | |
| SCHEMBL29113020 | 0.77 | RRM2 (0.54) | RRM2RRM1RRM2BCISD1NAPRT | |
| Phenylthiourea SCHEMBL28693164 | 0.74 | ALDH1A1 (0.53) | RRM2RRM1RRM2BCISD1SMN1; SMN2 | |
| SCHEMBL14125804 | 0.73 | PARP1 (0.53) | NAPRTPARP1LMNASMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020007106-A1 | MEDICAL USE OF EVOFOSFAMIDE IN ANTI-CANCER | 深圳艾欣达伟医药科技有限公司 | 2020-01-09 | — | — | WO | disclosed |