Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB5 | P28074 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.38 |
| ▸ | AXL | P30530 | 2/20 | 0.38 |
| ▸ | CDK8 | P49336 | 2/20 | 0.38 |
| ▸ | KDR | P35968 | 2/20 | 0.38 |
| ▸ | FLT3 | P36888 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23319684 | 0.85 | MAP4K4 (0.44) | PSMB5MAP4K4RAB9ATDP1 | |
| SCHEMBL24011937 | 0.83 | PDGFRB (0.43) | MAP4K4PDGFRBPDGFRAGSK3BPIM1 | |
| SCHEMBL24011728 | 0.82 | ESR2 (0.47) | MAP4K4MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL23319558 | 0.81 | PSMB5 (0.43) | PSMB5MAP4K4MAPTCASP1L3MBTL1 | |
| SCHEMBL21613445 | 0.81 | PSMB5 (0.45) | PSMB5MAP4K4MAPTCASP1NPC1 | |
| SCHEMBL21613442 | 0.79 | PSMB5 (0.44) | PSMB5MAP4K4MAPTCASP1NPC1 | |
| SCHEMBL18136475 | 0.75 | PSMB5 (0.53) | PSMB5MAP4K4MAPTCASP1NPC1 | |
| SCHEMBL23280655 | 0.74 | PRMT5 (0.34) | MAP4K4PDGFRBPDGFRAAXL | |
| SCHEMBL24229449 | 0.74 | PDGFRB (0.43) | MAP4K4PDGFRBPDGFRABLKCSNK1G2 | |
| SCHEMBL10205844 | 0.73 | PSMB5 (0.51) | PSMB5MAP4K4MAPTCASP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3319963-B1 | SUBSTITUTED 4-AZAINDOLES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2020-01-08 | — | — | EP | disclosed |