Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.40 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | F10 | P00742 | 1/20 | 0.40 |
| ▸ | RHEB | Q15382 | 1/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.40 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.39 |
| ▸ | CSNK1E | P49674 | 3/20 | 0.39 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.39 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.39 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.39 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.39 |
| ▸ | KLK1 | P06870 | 1/20 | 0.39 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30579942 | 0.83 | HSD17B10 (0.39) | CYP2C19PDE10ACACNA1HKLK1KLK5 | |
| SCHEMBL24027385 | 0.82 | GAA (0.50) | GAAHTTCACNA1GF10RHEB | |
| SCHEMBL30040328 | 0.79 | CYP1A2 (0.42) | CYP2C19PDE10AKLK1KLK5CYP1A2 | |
| SCHEMBL25402812 | 0.79 | CYP1A2 (0.42) | CYP2C19PDE10AKLK1KLK5CYP1A2 | |
| SCHEMBL21611976 | 0.79 | SMARCA2 (0.49) | GAAHTTCACNA1GSMARCA2SMARCA4 | |
| Hydrochloric Acid SCHEMBL10509797 | 0.79 | RHEB (0.51) | GAAHTTCACNA1GF10RHEB | |
| SCHEMBL21614711 | 0.78 | RAB9A (0.45) | GAAHTTCACNA1GF10PDE10A | |
| SCHEMBL21611957 | 0.78 | CYP3A4 (0.45) | CYP2C19PDE10AKLK1KLK5CYP1A2 | |
| SCHEMBL21614777 | 0.78 | CYP3A4 (0.54) | CYP2C19PDE10ACYP1A2TSHRHDAC1 | |
| SCHEMBL23618342 | 0.77 | IDH2 (0.41) | PDE10AHDAC1HDAC6IDH1IDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210353606-A1 | PqsR INVERSE AGONISTS | Helmholtz-Zentrum für Infektionsforschung GmbH (DE) | 2021-11-18 | — | — | US | disclosed |
| WO-2020007938-A1 | PqsR INVERSE AGONISTS | Helmholtz-Zentrum für Infektionsforschung GmbH (DE) | 2020-01-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210353606-A1 | PqsR INVERSE AGONISTS | QRFPR, P2RY11, QARS1 | GAA 3075/4885HTT 3291/4885CACNA1G 2869/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.