Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY14 | Q15391 | 8/20 | 0.37 |
| ▸ | FPR1 | P21462 | 1/20 | 0.37 |
| ▸ | FPR2 | P25090 | 1/20 | 0.37 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | CCR2 | P41597 | 1/20 | 0.36 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.35 |
| ▸ | PROKR1 | Q8TCW9 | 2/20 | 0.35 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.35 |
| ▸ | DRD1 | P21728 | 1/20 | 0.35 |
| ▸ | DRD5 | P21918 | 1/20 | 0.35 |
| ▸ | HTR1D | P28221 | 1/20 | 0.35 |
| ▸ | HTR1E | P28566 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23632375 | 1.00 | P2RY14 (0.37) | P2RY14FPR1FPR2SRD5A2KCNH2 | |
| SCHEMBL23631928 | 1.00 | P2RY14 (0.37) | P2RY14FPR1FPR2SRD5A2KCNH2 | |
| SCHEMBL28616314 | 1.00 | P2RY14 (0.37) | P2RY14FPR1FPR2SRD5A2KCNH2 | |
| SCHEMBL28542875 | 0.91 | SRD5A2 (0.37) | P2RY14FPR1FPR2SRD5A2PTGER4 | |
| SCHEMBL23631881 | 0.91 | CCR2 (0.41) | FPR1FPR2KCNH2CCR2NOTUM | |
| SCHEMBL28529252 | 0.91 | CCR2 (0.41) | FPR1FPR2KCNH2CCR2NOTUM | |
| SCHEMBL23632088 | 0.88 | P2RY14 (0.38) | P2RY14FPR1FPR2SRD5A2KCNH2 | |
| SCHEMBL21616645 | 0.88 | P2RY14 (0.38) | P2RY14FPR1FPR2SRD5A2KCNH2 | |
| SCHEMBL28626815 | 0.88 | P2RY14 (0.38) | P2RY14FPR1FPR2SRD5A2KCNH2 | |
| SCHEMBL28614536 | 0.88 | P2RY14 (0.38) | P2RY14FPR1FPR2SRD5A2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112513021-B | ROR gamma antagonist and application thereof in medicines | 广东东阳光药业有限公司 | 2023-06-27 | — | — | CN | disclosed |
| CN-112513021-A | ROR gamma antagonist and application thereof in medicine | 广东东阳光药业有限公司 | 2021-03-16 | — | — | CN | disclosed |
| WO-2020011147-A1 | RORγ ANTAGONIST AND APPLICATION THEREOF IN MEDICINE | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2020-01-16 | — | — | WO | disclosed |