SCHEMBL21617208

SCHEMBL21617208

CCCC(C)NC(=O)c1cccc(Nc2ccc(OCc3ccccn3)cc2C)c1

nearest known ligand 0.48

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ GPR132 Q9UNW8 4/20 0.48
▸ ALDH1A1 P00352 1/20 0.48
▸ LMNA P02545 1/20 0.48
▸ SMN1; SMN2 Q16637 1/20 0.48
▸ SMO Q99835 7/20 0.46
▸ MAPK14 Q16539 5/20 0.46
▸ KCNH2 Q12809 2/20 0.41
▸ CYP2C9 P11712 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31504335 1.00 GPR132 (0.48) GPR132ALDH1A1LMNASMN1; SMN2SMO
SCHEMBL31504352 0.92 GPR132 (0.49) GPR132ALDH1A1LMNASMN1; SMN2SMO
SCHEMBL21617233 0.92 GPR132 (0.49) GPR132ALDH1A1LMNASMN1; SMN2SMO
SCHEMBL21617295 0.88 ALDH1A1 (0.52) GPR132ALDH1A1LMNASMN1; SMN2SMO
SCHEMBL31504364 0.88 ALDH1A1 (0.52) GPR132ALDH1A1LMNASMN1; SMN2SMO
SCHEMBL21617162 0.85 SMO (0.46) GPR132SMOMAPK14KCNH2CYP2C9
SCHEMBL31504407 0.85 SMO (0.46) GPR132SMOMAPK14KCNH2CYP2C9
SCHEMBL21617238 0.84 BRD4 (0.47) GPR132SMOMAPK14KCNH2CYP2C9
SCHEMBL31504349 0.84 BRD4 (0.47) GPR132SMOMAPK14KCNH2CYP2C9
SCHEMBL21617209 0.83 BRD4 (0.49) GPR132SMN1; SMN2SMOMAPK14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3820850-B1 PHENYL/PYRIDYL-N-PHENYL/PYRIDYL DERIVATIVES FOR TREATING A RNA VIRUS INFECTION ABIVAX (FR) 2026-04-01 — — EP disclosed
US-12421206-B2 Aryl-n-aryl derivatives for treating a RNA virus infection ABIVAX (FR) 2025-09-23 — — US disclosed
EP-3820850-A1 PHENYL/PYRIDYL-N-PHENYL/PYRIDYL DERIVATIVES FOR TREATING A RNA VIRUS INFECTION ABIVAX (FR) 2021-05-19 — — EP disclosed
US-20210122732-A1 ARYL-N-ARYL DERIVATIVES FOR TREATING A RNA VIRUS INFECTION ABIVAX (FR) 2021-04-29 — — US disclosed
US-20210122732-A1 ARYL-N-ARYL DERIVATIVES FOR TREATING A RNA VIRUS INFECTION ABIVAX (FR) 2021-04-29 — — US disclosed
WO-2020011816-A1 PHENYL/PYRIDYL-N-PHENYL/PYRIDYL DERIVATIVES FOR TREATING A RNA VIRUS INFECTION ABIVAX (FR) 2020-01-16 — — WO disclosed
WO-2020011816-A1 PHENYL/PYRIDYL-N-PHENYL/PYRIDYL DERIVATIVES FOR TREATING A RNA VIRUS INFECTION ABIVAX (FR) 2020-01-16 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12421206-B2 Aryl-n-aryl derivatives for treating a RNA virus infection NSUN3, CBR3, C1R GPR132 2767/4885ALDH1A1 3246/4885LMNA 4069/4885
US-20210122732-A1 ARYL-N-ARYL DERIVATIVES FOR TREATING A RNA VIRUS INFECTION NSUN3, CBR3, C1R GPR132 2767/4885ALDH1A1 3246/4885LMNA 4069/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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