SCHEMBL21617285

SCHEMBL21617285

O=C(NCCC1CCCCC1)c1cccc(Nc2ccc(OCc3ccccn3)cc2)c1

nearest known ligand 0.53

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ HPGD P15428 2/20 0.45
▸ MEN1 O00255 1/20 0.45
▸ KMT2A Q03164 1/20 0.45
▸ GPR132 Q9UNW8 1/20 0.43
▸ MAPK14 Q16539 4/20 0.43
▸ SMO Q99835 2/20 0.43
▸ ALOX5 P09917 1/20 0.43
▸ CHRM4 P08173 2/20 0.42
▸ PARP10 Q53GL7 1/20 0.42
▸ KIT P10721 1/20 0.42
▸ RECQL P46063 1/20 0.41
▸ RHOA P61586 1/20 0.41
▸ LDLR P01130 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31504443 1.00 HPGD (0.45) HPGDMEN1KMT2AGPR132MAPK14
SCHEMBL31504383 0.99 GPR132 (0.44) HPGDMEN1KMT2AGPR132MAPK14
SCHEMBL21617201 0.99 GPR132 (0.44) HPGDMEN1KMT2AGPR132MAPK14
SCHEMBL21617237 0.97 GPR132 (0.44) HPGDMEN1KMT2AGPR132MAPK14
SCHEMBL31504406 0.97 GPR132 (0.44) HPGDMEN1KMT2AGPR132MAPK14
SCHEMBL21617274 0.95 GPR132 (0.45) GPR132MAPK14SMOCHRM4PARP10
SCHEMBL31504336 0.95 GPR132 (0.45) GPR132MAPK14SMOCHRM4PARP10
SCHEMBL21617242 0.90 MEN1 (0.47) MEN1KMT2AGPR132MAPK14SMO
SCHEMBL31504392 0.90 MEN1 (0.47) MEN1KMT2AGPR132MAPK14SMO
SCHEMBL21617243 0.89 LDLR (0.45) HPGDMEN1KMT2AGPR132MAPK14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3820850-B1 PHENYL/PYRIDYL-N-PHENYL/PYRIDYL DERIVATIVES FOR TREATING A RNA VIRUS INFECTION ABIVAX (FR) 2026-04-01 — — EP disclosed
US-12421206-B2 Aryl-n-aryl derivatives for treating a RNA virus infection ABIVAX (FR) 2025-09-23 — — US disclosed
EP-3820850-A1 PHENYL/PYRIDYL-N-PHENYL/PYRIDYL DERIVATIVES FOR TREATING A RNA VIRUS INFECTION ABIVAX (FR) 2021-05-19 — — EP disclosed
US-20210122732-A1 ARYL-N-ARYL DERIVATIVES FOR TREATING A RNA VIRUS INFECTION ABIVAX (FR) 2021-04-29 — — US disclosed
US-20210122732-A1 ARYL-N-ARYL DERIVATIVES FOR TREATING A RNA VIRUS INFECTION ABIVAX (FR) 2021-04-29 — — US disclosed
WO-2020011816-A1 PHENYL/PYRIDYL-N-PHENYL/PYRIDYL DERIVATIVES FOR TREATING A RNA VIRUS INFECTION ABIVAX (FR) 2020-01-16 — — WO disclosed
WO-2020011816-A1 PHENYL/PYRIDYL-N-PHENYL/PYRIDYL DERIVATIVES FOR TREATING A RNA VIRUS INFECTION ABIVAX (FR) 2020-01-16 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12421206-B2 Aryl-n-aryl derivatives for treating a RNA virus infection NSUN3, CBR3, C1R HPGD 3998/4885MEN1 3986/4885KMT2A 2374/4885
US-20210122732-A1 ARYL-N-ARYL DERIVATIVES FOR TREATING A RNA VIRUS INFECTION NSUN3, CBR3, C1R HPGD 3998/4885MEN1 3986/4885KMT2A 2374/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

Send feedback