Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 6/20 | 0.44 |
| ▸ | HTT | P42858 | 5/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | ATF4 | P18848 | 3/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | CETP | P11597 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21621148 | 0.93 | ATF4 (0.47) | HDAC4MAPTHTTMEN1KMT2A | |
| SCHEMBL23773097 | 0.85 | ATF4 (0.49) | HDAC4MAPTHTTMEN1KMT2A | |
| SCHEMBL21621065 | 0.85 | ATF4 (0.45) | MAPTMEN1KMT2AATF4NPC1 | |
| SCHEMBL21621077 | 0.85 | NPC1 (0.48) | MAPTMAPK1LMNAALDH1A1GAA | |
| SCHEMBL21621133 | 0.84 | ATF4 (0.48) | MEN1KMT2AATF4 | |
| SCHEMBL23773258 | 0.80 | ATF4 (0.56) | MEN1KMT2AALDH1A1ATF4 | |
| SCHEMBL23773253 | 0.79 | ATF4 (0.56) | HDAC4MAPTHTTMEN1KMT2A | |
| SCHEMBL23773229 | 0.79 | ATF4 (0.54) | HDAC4ATF4 | |
| SCHEMBL21621079 | 0.78 | ATF4 (0.51) | MAPTHTTMEN1KMT2AMAPK1 | |
| SCHEMBL23773390 | 0.75 | ATF4 (0.58) | ATF4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020012339-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2020-01-16 | — | — | WO | disclosed |