Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATF4 | P18848 | 3/20 | 0.49 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.46 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.45 |
| ▸ | MEN1 | O00255 | 6/20 | 0.45 |
| ▸ | HTT | P42858 | 4/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
| ▸ | PDE4A | P27815 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.45 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.45 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21621079 | 0.80 | ATF4 (0.51) | ATF4GRIN1GRIN2BKMT2AMEN1 | |
| SCHEMBL21618334 | 0.80 | ATF4 (0.60) | ATF4KMT2AMEN1HTTNPC1 | |
| SCHEMBL12335085 | 0.79 | NPC1 (0.56) | GRIN1GRIN2BKMT2AMEN1HTT | |
| SCHEMBL31233718 | 0.71 | MEN1 (0.71) | KMT2AMEN1HTTLMNAHPGD | |
| SCHEMBL21621112 | 0.70 | MEN1 (0.45) | ATF4GRIN1GRIN2BKMT2AMEN1 | |
| SCHEMBL21618336 | 0.70 | ATF4 (0.68) | ATF4KMT2AMEN1HTTNPC1 | |
| SCHEMBL19569429 | 0.70 | ATF4 (0.82) | ATF4 | |
| SCHEMBL21618328 | 0.70 | ATF4 (0.57) | ATF4KMT2AMEN1NPC1RAB9A | |
| SCHEMBL23773091 | 0.69 | LMNA (0.45) | ATF4GRIN1GRIN2BKMT2AMEN1 | |
| SCHEMBL12334454 | 0.69 | EPHX2 (0.59) | KMT2ANPC1EPHX2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020012339-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2020-01-16 | — | — | WO | disclosed |