SCHEMBL21621465

SCHEMBL21621465

CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(=O)Oc1c(-c2ccc(O)c(O)c2)oc2cc(OC(C)C)cc(O)c2c1=O

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PLG P00747 1/20 0.52
NOX4 Q9NPH5 1/20 0.52
SRC P12931 7/20 0.50
POLH Q9Y253 5/20 0.50
KDM4E B2RXH2 2/20 0.48
MEN1 O00255 2/20 0.48
MAPT P10636 2/20 0.48
RECQL P46063 2/20 0.48
KMT2A Q03164 2/20 0.48
HSD17B10 Q99714 2/20 0.48
MMP1 P03956 1/20 0.48
POLB P06746 1/20 0.48
GAA P10253 1/20 0.48
APEX1 P27695 1/20 0.48
HTT P42858 1/20 0.48
BLM P54132 1/20 0.48
EPHX2 P34913 1/20 0.47
LMNA P02545 1/20 0.46
APP P05067 1/20 0.46
CYP3A4 P08684 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23326102 1.00 PLG (0.52) PLGNOX4SRCPOLHKDM4E
SCHEMBL21621466 0.94 TOP2A (0.51) PLGNOX4SRCPOLHKDM4E
SCHEMBL21621460 0.90 POLH (0.51) NOX4SRCPOLHKDM4EMEN1
SCHEMBL23326103 0.90 POLH (0.51) NOX4SRCPOLHKDM4EMEN1
SCHEMBL469569 0.90 POLH (0.63) PLGNOX4SRCPOLHKDM4E
SCHEMBL23326261 0.90 POLH (0.63) PLGNOX4SRCPOLHKDM4E
SCHEMBL455660 0.90 POLH (0.63) PLGNOX4SRCPOLHKDM4E
SCHEMBL455661 0.90 POLH (0.63) PLGNOX4SRCPOLHKDM4E
SCHEMBL21621461 0.89 POLH (0.51) PLGNOX4SRCPOLHKDM4E
SCHEMBL21621478 0.84 TOP2A (0.51) SRCPOLHKDM4EMEN1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12195437-B2 Lipophenolic flavonoid derivatives useful to reduce carbonyl and oxidative stresses (COS) CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) 2025-01-14 US disclosed
US-20210139447-A1 Lipophenolic Flavonoid Derivatives Useful To Reduce Carbonyl And Oxidative Stresses (COS) CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) 2021-05-13 US disclosed
US-20210139447-A1 Lipophenolic Flavonoid Derivatives Useful To Reduce Carbonyl And Oxidative Stresses (COS) CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) 2021-05-13 US disclosed
WO-2020012003-A1 LIPOPHENOLIC FLAVONOID DERIVATIVES USEFUL TO REDUCE CARBONYL AND OXIDATIVE STRESSES (COS) CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) 2020-01-16 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12195437-B2 Lipophenolic flavonoid derivatives useful to reduce carbonyl and oxidative stresses (COS) LPO, NQO1, CAT PLG 4136/4885NOX4 124/4885SRC 3798/4885
US-20210139447-A1 Lipophenolic Flavonoid Derivatives Useful To Reduce Carbonyl And Oxidative Stresses (COS) LPO, NQO1, CAT PLG 4136/4885NOX4 124/4885SRC 3798/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.