Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8022098 | 0.85 | CYP2C19 (0.44) | ABHD6HSD17B10KMT2ACYP2C19MAPT | |
| SCHEMBL30033295 | 0.85 | CYP2C19 (0.44) | ABHD6HSD17B10KMT2ACYP2C19MAPT | |
| SCHEMBL25690672 | 0.78 | ABHD6 (0.47) | ABHD6HSD17B10HTTKMT2A | |
| SCHEMBL14881091 | 0.78 | ABHD6 (0.47) | ABHD6HSD17B10HTTKMT2ASMN1; SMN2 | |
| SCHEMBL14907172 | 0.78 | CCR1 (0.34) | HRH4CYP2C19CYP2C9 | |
| SCHEMBL19080449 | 0.76 | SLC6A2 (0.34) | ABHD6CYP2C19SMN1; SMN2CYP2C9 | |
| SCHEMBL21937114 | 0.75 | ABHD6 (0.42) | ABHD6HTTCYP2C19MAPT | |
| SCHEMBL21802762 | 0.75 | ABHD6 (0.58) | ABHD6HTTKMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL12341045 | 0.73 | HPGD (0.34) | ABHD6HRH3HTTCYP2C19BRD4 | |
| SCHEMBL12344128 | 0.73 | HRH3 (0.40) | HRH4HRH3CYP2C19MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3822266-A1 | PYRROLIDINYL UREA DERIVATIVES AND APPLICATION THEREOF IN TRKA-RELATED DISEASES | Zhangzhou Pien Tze Huang Pharmaceutical Co., Ltd (CN) | 2021-05-19 | — | — | EP | disclosed |
| WO-2020083377-A1 | PYRROLIDINYL UREA DERIVATIVES AND APPLICATION THEREOF | 南京明德新药研发有限公司 | 2020-04-30 | — | — | WO | disclosed |
| WO-2020011227-A1 | PYRROLIDINYL UREA DERIVATIVES AND APPLICATION THEREOF IN TRKA-RELATED DISEASES | 南京明德新药研发有限公司 | 2020-01-16 | — | — | WO | disclosed |