Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 4/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.30 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22652447 | 0.78 | KCNH2 (0.34) | ABHD6 | |
| SCHEMBL20364793 | 0.78 | KCNH2 (0.34) | ABHD6 | |
| SCHEMBL18375025 | 0.78 | LMNA (0.39) | — | |
| SCHEMBL14907172 | 0.78 | CCR1 (0.34) | SLC6A2SLC6A4SLC6A3CYP2C19CYP2D6 | |
| SCHEMBL21622374 | 0.76 | ABHD6 (0.44) | CYP2C19SMN1; SMN2CYP2C9ABHD6 | |
| SCHEMBL17624441 | 0.76 | SLC6A9 (0.41) | SMN1; SMN2SSTR4 | |
| SCHEMBL12341045 | 0.73 | HPGD (0.34) | CYP2C19ABHD6 | |
| SCHEMBL12344128 | 0.73 | HRH3 (0.40) | SLC6A2SLC6A4SLC6A3CYP2C19CYP2D6 | |
| SCHEMBL20652025 | 0.73 | KCNH2 (0.40) | — | |
| SCHEMBL24388850 | 0.71 | MAPK1 (0.36) | OPRL1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017117447-A1 | MULTICYCLIC COMPOUNDS AND USES THEREOF | Karyopharm Therapeutics Inc. (US) | 2017-07-06 | — | — | WO | disclosed |