SCHEMBL21622972

SCHEMBL21622972

C1=CC2=CC=Cc3cc4c(cc3N2C=C1)[nH]c1ccccc14

nearest known ligand 0.42

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
AHR P35869 1/20 0.42
ALDH1A1 P00352 2/20 0.36
HSD17B10 Q99714 2/20 0.36
GPR3 P46089 1/20 0.36
KIF11 P52732 11/20 0.35
KDM4E B2RXH2 2/20 0.33
MAPT P10636 2/20 0.33
ATM Q13315 1/20 0.33
MEN1 O00255 1/20 0.33
HPGD P15428 1/20 0.33
KMT2A Q03164 1/20 0.33
TOP2A P11388 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24489628 0.76 AHR (0.41) AHRALDH1A1HSD17B10GPR3KIF11
SCHEMBL693565 0.71 LMNA (0.32)
SCHEMBL12219476 0.64 AHR (1.00) AHRALDH1A1HSD17B10GPR3KIF11
SCHEMBL12219478 0.64 AHR (1.00) AHRALDH1A1HSD17B10GPR3KIF11
SCHEMBL550602 0.64 AHR (1.00) AHRALDH1A1HSD17B10GPR3KIF11
SCHEMBL29380459 0.64 AHR (1.00) AHRALDH1A1HSD17B10GPR3KIF11
SCHEMBL17072805 0.64 AHR (0.46) AHRALDH1A1HSD17B10GPR3KIF11
SCHEMBL17072697 0.63 AHR (0.86) AHRALDH1A1HSD17B10GPR3KIF11
SCHEMBL16195631 0.63 AHR (0.86) AHRALDH1A1HSD17B10GPR3KIF11
SCHEMBL31453782 0.63 AHR (0.86) AHRALDH1A1HSD17B10GPR3KIF11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020011686-A1 MATERIALS FOR ORGANIC ELECTROLUMINESCENT DEVICES MERCK PATENT GMBH (DE) 2020-01-16 WO disclosed