Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | SCN4A | P35499 | 1/20 | 0.32 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | P2RX4 | Q99571 | 3/20 | 0.31 |
| ▸ | P2RX1 | P51575 | 2/20 | 0.31 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3732224 | 0.77 | P2RX4 (0.35) | LMNATSHRMAPK1SCN4ASCN5A | |
| SCHEMBL19284163 | 0.74 | MGLL (0.40) | LMNATSHRMAPK1SCN4ASCN5A | |
| SCHEMBL27881193 | 0.73 | — | — | |
| SCHEMBL21622972 | 0.71 | AHR (0.42) | — | |
| SCHEMBL10345865 | 0.70 | HTT (0.31) | LMNATSHRMAPK1P2RX4 | |
| SCHEMBL11498008 | 0.70 | — | — | |
| SCHEMBL6312853 | 0.70 | LMNA (0.41) | LMNATSHRMAPK1SCN4ASCN5A | |
| SCHEMBL7414781 | 0.68 | LMNA (0.35) | LMNATSHRMAPK1SCN4ASCN5A | |
| SCHEMBL1249107 | 0.68 | MTNR1A (0.39) | LMNATSHRMAPK1SCN4ASCN5A | |
| SCHEMBL9030868 | 0.68 | LMNA (0.35) | LMNATSHRMAPK1SCN4ASCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421870-A2 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | Abbott Laboratories (US) | 2012-02-29 | — | — | EP | disclosed |
| WO-2010124042-A2 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2010-10-28 | — | — | WO | disclosed |