SCHEMBL21623514

SCHEMBL21623514

CC(C)NC(=O)c1c(Nc2ccc(OCc3ccccc3)cc2C2CC2)cccc1C(F)(F)F

nearest known ligand 0.42

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
▸ MAOA P21397 2/20 0.42
▸ MAOB P27338 1/20 0.42
▸ PTGES O14684 1/20 0.41
▸ S1PR1 P21453 12/20 0.39
▸ S1PR4 O95977 2/20 0.39
▸ S1PR5 Q9H228 2/20 0.39
▸ NR1H2 P55055 1/20 0.38
▸ NR1H3 Q13133 1/20 0.38
▸ ADORA3 P0DMS8 1/20 0.38
▸ MRGPRX4 Q96LA9 1/20 0.38
▸ SMPD1 P17405 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21617212 0.89 PTGES (0.45) MAOAMAOBPTGESMRGPRX4SMPD1
SCHEMBL31504440 0.89 PTGES (0.45) MAOAMAOBPTGESMRGPRX4SMPD1
SCHEMBL21617266 0.88 PTGES (0.44) MAOAMAOBPTGESS1PR1S1PR5
SCHEMBL31504425 0.88 PTGES (0.44) MAOAMAOBPTGESS1PR1S1PR5
SCHEMBL21617219 0.87 PTGES (0.43) MAOAMAOBPTGESS1PR1S1PR5
SCHEMBL31504380 0.87 PTGES (0.43) MAOAMAOBPTGESS1PR1S1PR5
SCHEMBL21617288 0.84 PTGES (0.41) MAOAMAOBPTGESS1PR1MRGPRX4
SCHEMBL31504402 0.84 PTGES (0.41) MAOAMAOBPTGESS1PR1MRGPRX4
SCHEMBL23308007 0.83 MAOB (0.39) MAOAMAOBS1PR1S1PR4S1PR5
SCHEMBL23308016 0.73 CNR2 (0.42) —

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3820850-B1 PHENYL/PYRIDYL-N-PHENYL/PYRIDYL DERIVATIVES FOR TREATING A RNA VIRUS INFECTION ABIVAX (FR) 2026-04-01 — — EP disclosed
US-12421206-B2 Aryl-n-aryl derivatives for treating a RNA virus infection ABIVAX (FR) 2025-09-23 — — US disclosed
CN-112638877-B Phenyl/pyridinyl-N-phenyl/pyridinyl derivatives for the treatment of RNA viral infections ABIVAX公司 2025-04-22 — — CN disclosed
US-20210122732-A1 ARYL-N-ARYL DERIVATIVES FOR TREATING A RNA VIRUS INFECTION ABIVAX (FR) 2021-04-29 — — US disclosed
US-20210122732-A1 ARYL-N-ARYL DERIVATIVES FOR TREATING A RNA VIRUS INFECTION ABIVAX (FR) 2021-04-29 — — US disclosed
WO-2020011816-A1 PHENYL/PYRIDYL-N-PHENYL/PYRIDYL DERIVATIVES FOR TREATING A RNA VIRUS INFECTION ABIVAX (FR) 2020-01-16 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12421206-B2 Aryl-n-aryl derivatives for treating a RNA virus infection NSUN3, CBR3, C1R MAOA 1648/4885MAOB 2297/4885PTGES 3685/4885
US-20210122732-A1 ARYL-N-ARYL DERIVATIVES FOR TREATING A RNA VIRUS INFECTION NSUN3, CBR3, C1R MAOA 1648/4885MAOB 2297/4885PTGES 3685/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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