Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.46 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SLC6A9 | P48067 | 7/20 | 0.42 |
| ▸ | ACACB | O00763 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | SCD | O00767 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21624873 | 1.00 | HRH3 (0.48) | HRH3KDM4EABL1LMNAGPR119 | |
| SCHEMBL29165956 | 1.00 | HRH3 (0.48) | HRH3KDM4EABL1LMNAGPR119 | |
| SCHEMBL27173002 | 0.92 | KDM4E (0.48) | HRH3KDM4EABL1LMNAGPR119 | |
| SCHEMBL28968501 | 0.89 | GPR119 (0.48) | HRH3KDM4EABL1LMNAGPR119 | |
| SCHEMBL28789275 | 0.84 | KDM4E (0.44) | KDM4EABL1LMNASLC6A9 | |
| SCHEMBL28789231 | 0.84 | KDM4E (0.44) | KDM4EABL1LMNASLC6A9 | |
| SCHEMBL28789217 | 0.84 | KDM4E (0.44) | KDM4EABL1LMNASLC6A9 | |
| SCHEMBL28789156 | 0.84 | KDM4E (0.44) | KDM4EABL1LMNASLC6A9 | |
| SCHEMBL28547150 | 0.83 | ACACB (0.42) | HRH3GPR119ACACB | |
| SCHEMBL28603238 | 0.82 | ACACB (0.57) | HRH3KDM4EABL1LMNALIPG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020017569-A1 | T-TYPE CALCIUM CHANNEL BLOCKER | 日本ケミファ株式会社 | 2020-01-23 | — | — | WO | disclosed |