Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | SCD | O00767 | 1/20 | 0.40 |
| ▸ | CTSB | P07858 | 1/20 | 0.40 |
| ▸ | CTSS | P25774 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21624915 | 1.00 | LMNA (0.47) | LMNAHRH3SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL21624782 | 0.88 | SCD (0.47) | HRH3SMN1; SMN2RAB9ANPC1SCD | |
| SCHEMBL21624783 | 0.88 | SCD (0.47) | HRH3SMN1; SMN2RAB9ANPC1SCD | |
| SCHEMBL21624797 | 0.77 | LMNA (0.56) | LMNAHRH3SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL21624799 | 0.77 | LMNA (0.56) | LMNAHRH3SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL23387302 | 0.75 | LMNA (0.48) | LMNAHRH3SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL23387304 | 0.75 | LMNA (0.48) | LMNAHRH3SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL10185759 | 0.74 | LMNA (0.63) | LMNAHRH3SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL22499876 | 0.74 | CTSK (0.46) | LMNACTSK | |
| SCHEMBL29105931 | 0.74 | HRH3 (0.49) | HRH3SMN1; SMN2RAB9ANPC1SCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3825303-A1 | T-TYPE CALCIUM CHANNEL BLOCKER | Nippon Chemiphar Co., Ltd. (JP) | 2021-05-26 | — | — | EP | disclosed |
| WO-2020017569-A1 | T-TYPE CALCIUM CHANNEL BLOCKER | 日本ケミファ株式会社 | 2020-01-23 | — | — | WO | disclosed |