Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 19/20 | 0.53 |
| ▸ | PIK3R2 | O00459 | 19/20 | 0.53 |
| ▸ | PIK3CA | P42336 | 19/20 | 0.53 |
| ▸ | PIK3CB | P42338 | 19/20 | 0.53 |
| ▸ | PIK3CG | P48736 | 19/20 | 0.53 |
| ▸ | PIK3R5 | Q8WYR1 | 19/20 | 0.53 |
| ▸ | PIK3R3 | Q92569 | 19/20 | 0.53 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21625122 | 0.87 | PIK3CD (0.53) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL21625207 | 0.86 | SHMT2 (0.52) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL21625157 | 0.86 | SHMT2 (0.59) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL21636256 | 0.83 | SHMT2 (0.56) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL21625070 | 0.83 | PIK3CD (0.55) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL21625204 | 0.82 | ALDH1A1 (0.56) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL21625200 | 0.82 | CNR2 (0.50) | — | |
| SCHEMBL21625184 | 0.80 | SHMT2 (0.49) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL21625152 | 0.78 | SHMT2 (0.48) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL21625174 | 0.78 | SHMT2 (0.50) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020016315-A1 | FUSED DIHYDROINDAZOLE DERIVATIVES HAVING MULTIMODAL ACTIVITY AGAINST PAIN | ESTEVE PHARMACEUTICALS, S.A. (ES) | 2020-01-23 | — | — | WO | claimed |
| WO-2020016315-A1 | FUSED DIHYDROINDAZOLE DERIVATIVES HAVING MULTIMODAL ACTIVITY AGAINST PAIN | ESTEVE PHARMACEUTICALS, S.A. (ES) | 2020-01-23 | — | — | WO | disclosed |
| WO-2020016315-A1 | FUSED DIHYDROINDAZOLE DERIVATIVES HAVING MULTIMODAL ACTIVITY AGAINST PAIN | ESTEVE PHARMACEUTICALS, S.A. (ES) | 2020-01-23 | — | — | WO | disclosed |
| US-9394239-B2 | Biphenyl-3-carboxylic acid modulators of beta-3-adrenoreceptor | AUSPEX PHARMACEUTICALS, INC. (US) | 2016-07-19 | — | — | US | disclosed |